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Gene Review:

mes-2 - Protein MES-2

Caenorhabditis elegans

Kelly, W.G. et al., Capowski, E.E. et al., Holdeman, R. et al., Chesney, M.A. et al.

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High impact information on mes-2

We hypothesize that mes-2 encodes a maternal regulator of gene expression in the early germline; its function is essential for normal early development and viability of germ cells [1].
The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478) [2].
The majority of mutations, those in mes-2, mes-3 and mes-4, affect postembryonic germ-line development; the progeny of mutant mothers undergo apparently normal embryogenesis but develop into agametic adults with 10-1000-fold reductions in number of germ cells [3].

Biological context of mes-2

The gon-14 larval arrest is suppressed by loss of mes-2/E(Z), mes-6/ESC, or mes-4, which encodes a SET domain protein [4].

References

MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Holdeman, R., Nehrt, S., Strome, S. Development (1998) [Pubmed]
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans. Kelly, W.G., Fire, A. Development (1998) [Pubmed]
Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. Capowski, E.E., Martin, P., Garvin, C., Strome, S. Genetics (1991) [Pubmed]
gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Chesney, M.A., Kidd, A.R., Kimble, J. Genetics (2006) [Pubmed]

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