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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gon-1  -  Protein GON-1

Caenorhabditis elegans

 
 
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High impact information on gon-1

  • In the nematode Caenorhabditis elegans, the gonad acquires a U-shape by the directed migration of a specialized 'leader' cell, which is located at the tip of the growing gonadal 'arm'. The gon-1 gene is essential for gonadal morphogenesis: in gon-1 mutants, no arm elongation occurs and somatic gonadal structures are severely malformed [1].
  • We find that gon-1 is expressed in two sites, leader cells and muscle, and that expression in each site has a unique role in forming the gonad [1].
  • Parallel studies have shown that gon-1 encodes a secreted metalloprotease (R. Blelloch and J. Kimble, 1999, Nature 399, 586-590) [2].

References

  1. Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. Blelloch, R., Kimble, J. Nature (1999) [Pubmed]
  2. The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans. Blelloch, R., Anna-Arriola, S.S., Gao, D., Li, Y., Hodgkin, J., Kimble, J. Dev. Biol. (1999) [Pubmed]
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