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ADAMTS9  -  ADAM metallopeptidase with thrombospondin...

Homo sapiens

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 9, ADAM-TS 9, ADAM-TS9, ADAMTS-9, KIAA1312
 
 
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Disease relevance of ADAMTS9

  • ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes [1].
  • Thus, this study identifies and provides functional evidence for a CR associated with tumor suppression on 3p14.2 and provides the first evidence that ADAMTS9, mapping to this region, may contribute to esophageal cancer development.Oncogene (2007) 26, 148-157. doi:10.1038/sj.onc.1209767; published online 26 June 2006 [2].
  • Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9 [2].
 

High impact information on ADAMTS9

 

Biological context of ADAMTS9

 

Anatomical context of ADAMTS9

  • In contrast to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues [4].
  • In C. elegans, the GON-1 ADAMTS metalloprotease regulates both elongation and shape of the developing gonad . Here, we report that either human ADAMTS-4 or ADAMTS-9 can substitute for GON-1 in transgenic worms, suggesting functional conservation between human and nematode homologs [6].
 

Other interactions of ADAMTS9

  • Following stimulation with TNFalpha, ADAMTS1, ADAMTS6 and both ADAMTS9 transcripts expressed in ARPE-19 cells showed a potent upregulation [7].
  • The expression of mRNA isoforms for ADAMTS7 and ADAMTS9 were also detected [7].
  • TNFalpha alone induced ADAMTS-9 expression, whereas OSM addition caused suppression [8].
  • We probed pathologenomic activities (activation and functional activity) of ADAM19 and ADAMTS9 using siRNA and collagen assays [9].
 

Analytical, diagnostic and therapeutic context of ADAMTS9

  • ADAMTS-9 protein was examined by Western blotting, and the role of the MAPK signaling pathway for ADAMTS9 induction in IL-1beta-stimulated OUMS-27 cells was investigated [1].

References

  1. ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Demircan, K., Hirohata, S., Nishida, K., Hatipoglu, O.F., Oohashi, T., Yonezawa, T., Apte, S.S., Ninomiya, Y. Arthritis Rheum. (2005) [Pubmed]
  2. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Lo, P.H., Leung, A.C., Kwok, C.Y., Cheung, W.S., Ko, J.M., Yang, L.C., Law, S., Wang, L.D., Li, J., Stanbridge, E.J., Srivastava, G., Tang, J.C., Tsao, S.W., Lung, M.L. Oncogene (2007) [Pubmed]
  3. Cell-surface Processing of Pro-ADAMTS9 by Furin. Koo, B.H., Longpré, J.M., Somerville, R.P., Alexander, J.P., Leduc, R., Apte, S.S. J. Biol. Chem. (2006) [Pubmed]
  4. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family. Clark, M.E., Kelner, G.S., Turbeville, L.A., Boyer, A., Arden, K.C., Maki, R.A. Genomics (2000) [Pubmed]
  5. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. Somerville, R.P., Longpre, J.M., Jungers, K.A., Engle, J.M., Ross, M., Evanko, S., Wight, T.N., Leduc, R., Apte, S.S. J. Biol. Chem. (2003) [Pubmed]
  6. GON-1 and fibulin have antagonistic roles in control of organ shape. Hesselson, D., Newman, C., Kim, K.W., Kimble, J. Curr. Biol. (2004) [Pubmed]
  7. Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha. Bevitt, D.J., Mohamed, J., Catterall, J.B., Li, Z., Arris, C.E., Hiscott, P., Sheridan, C., Langton, K.P., Barker, M.D., Clarke, M.P., McKie, N. Biochim. Biophys. Acta (2003) [Pubmed]
  8. Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. Hui, W., Barksby, H.E., Young, D.A., Cawston, T.E., McKie, N., Rowan, A.D. Ann. Rheum. Dis. (2005) [Pubmed]
  9. Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells. Keating, D.T., Sadlier, D.M., Patricelli, A., Smith, S.M., Walls, D., Egan, J.J., Doran, P.P. Respir. Res. (2006) [Pubmed]
 
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