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Gene Review

dhp-2  -  Protein DHP-2

Caenorhabditis elegans

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High impact information on dhp-2

  • These newly isolated molecules were believed to represent a common ancestral state before the gene duplication between CRMPs and DHP [1].
  • In this study we isolated two cDNA clones from nematode C. elegans based on their sequence homology to vertebrate CRMPs and DHP [1].
  • These CRMPs exhibit about 60% amino acid identity with vertebrate dihydropyrimidinase (DHP), an amidohydrolase involved in the pyrimidine degradation pathway [1].


  1. Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase? Takemoto, T., Sasaki, Y., Hamajima, N., Goshima, Y., Nonaka, M., Kimura, H. Gene (2000) [Pubmed]
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