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Gene Review

DPYS  -  dihydropyrimidinase

Homo sapiens

Synonyms: DHP, DHPase, Dihydropyrimidinase, Dihydropyrimidine amidohydrolase, Hydantoinase
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Disease relevance of DPYS


High impact information on DPYS


Chemical compound and disease context of DPYS

  • Indeed, the data from dihydropyridine-based calcium antagonist (DHP) trails are consistent in that they could not protect against new-onset heart failure or progression of renal disease in patients with left-ventricular systolic dysfunction or overt proteinuria, respectively [7].
  • A partial dihydropyrimidinase deficiency proved to be a novel pharmacogenetic disorder associated with severe 5FU toxicity [8].
  • These prospective studies will provide further valuable information whether nifedipine may be a preferred DHP to achieve BP goals in hypertensive patients with systolic dysfunction or overt proteinuria [7].

Biological context of DPYS


Anatomical context of DPYS

  • Exposure to DHP also resulted in increasedlhbmRNA levels toward final oocyte maturation [12].
  • Quantitative image analysis of the fluorescence emitted by the protoplasts showed the existence of interactions between PAA- and DHP-binding sites [13].
  • By using RT-PCR amplification, Western blot with antibodies directed against the alpha1D subunit, binding assays with specific agonists or antagonists, and inhibition with specific antisense oligonucleotides, we show that DHP receptors are expressed and functional in primary human monocytes [14].
  • Hepatocytes that contain both dihydropyrimidinase and dihydroorotase completely hydrolyzed dexrazoxane to ADR-925 and released it into the extracellular medium [15].
  • Treatment of postvitellogenic ovarian follicles with IGF-I and b-insulin increased concentration of maturation-inducing hormone (MIH), 17alpha,20beta-dihydroxy-4-pregnane-3-one (DHP) in the medium [16].

Associations of DPYS with chemical compounds


Other interactions of DPYS


Analytical, diagnostic and therapeutic context of DPYS


  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Hamajima, N., Matsuda, K., Sakata, S., Tamaki, N., Sasaki, M., Nonaka, M. Gene (1996) [Pubmed]
  2. pHluorin-based in vivo assay for hydrolase screening. Schuster, S., Enzelberger, M., Trauthwein, H., Schmid, R.D., Urlacher, V.B. Anal. Chem. (2005) [Pubmed]
  3. The structure of L-hydantoinase from Arthobacter aurescens leads to an understanding of dihydropyrimidinase substrate and enantio specificity. Abendroth, J., Niefind, K., May, O., Siemann, M., Syldatk, C., Schomburg, D. Biochemistry (2002) [Pubmed]
  4. Crystal structure of D-Hydantoinase from Burkholderia pickettii at a resolution of 2.7 Angstroms: insights into the molecular basis of enzyme thermostability. Xu, Z., Liu, Y., Yang, Y., Jiang, W., Arnold, E., Ding, J. J. Bacteriol. (2003) [Pubmed]
  5. Molecular evolution of hydantoinases. May, O., Habenicht, A., Mattes, R., Syldatk, C., Siemann, M. Biol. Chem. (1998) [Pubmed]
  6. Progestin is an essential factor for the initiation of the meiosis in spermatogenetic cells of the eel. Miura, T., Higuchi, M., Ozaki, Y., Ohta, T., Miura, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Revival of nifedipine, a dihydropyridine-based calcium blocker. Yamagishi, S., Nakamura, K. Med. Hypotheses (2007) [Pubmed]
  8. Pyrimidine degradation defects and severe 5-fluorouracil toxicity. van Kuilenburg, A.B., Meinsma, R., van Gennip, A.H. Nucleosides Nucleotides Nucleic Acids (2004) [Pubmed]
  9. Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene. Hamajima, N., Kouwaki, M., Vreken, P., Matsuda, K., Sumi, S., Imaeda, M., Ohba, S., Kidouchi, K., Nonaka, M., Sasaki, M., Tamaki, N., Endo, Y., De Abreu, R., Rotteveel, J., van Kuilenburg, A., van Gennip, A., Togari, H., Wada, Y. Am. J. Hum. Genet. (1998) [Pubmed]
  10. PYD2 encodes 5,6-dihydropyrimidine amidohydrolase, which participates in a novel fungal catabolic pathway. Gojkovic, Z., Jahnke, K., Schnackerz, K.D., Piskur, J. J. Mol. Biol. (2000) [Pubmed]
  11. Genetic heterogeneity in hypokalemic periodic paralysis (hypoPP). Plassart, E., Elbaz, A., Santos, J.V., Reboul, J., Lapie, P., Chauveau, D., Jurkat-Rott, K., Guimaraes, J., Saudubray, J.M., Weissenbach, J. Hum. Genet. (1994) [Pubmed]
  12. Sex steroids are involved in the regulation of gonadotropin-releasing hormone and dopamine d2 receptors in female tilapia pituitary. Levavi-Sivan, B., Biran, J., Fireman, E. Biol. Reprod. (2006) [Pubmed]
  13. Studies on ion channel antagonist-binding sites in sunflower protoplasts. Vallée, N., Brière, C., Petitprez, M., Barthou, H., Souvré, A., Alibert, G. FEBS Lett. (1997) [Pubmed]
  14. Human immunodeficiency virus type 1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors: involvement in TNF-alpha production. Contreras, X., Bennasser, Y., Chazal, N., Moreau, M., Leclerc, C., Tkaczuk, J., Bahraoui, E. Virology (2005) [Pubmed]
  15. Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Schroeder, P.E., Wang, G.Q., Burczynski, F.J., Hasinoff, B.B. Drug Metab. Dispos. (2005) [Pubmed]
  16. In vitro effects of insulin-like growth factors and insulin on oocyte maturation and maturation-inducing steroid production in ovarian follicles of common carp, Cyprinus carpio. Mukherjee, D., Mukherjee, D., Sen, U., Paul, S., Bhattacharyya, S.P. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2006) [Pubmed]
  17. Enzymes of uracil catabolism in normal and neoplastic human tissues. Naguib, F.N., el Kouni, M.H., Cha, S. Cancer Res. (1985) [Pubmed]
  18. Screening and diagnosis of beta-ureidopropionase deficiency by gas chromatographic/mass spectrometric analysis of urine. Ohse, M., Matsuo, M., Ishida, A., Kuhara, T. Journal of mass spectrometry : JMS. (2002) [Pubmed]
  19. Diagnosis and monitoring of inborn errors of metabolism using urease-pretreatment of urine, isotope dilution, and gas chromatography-mass spectrometry. Kuhara, T. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  20. Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. Thomas, H.R., Ezzeldin, H.H., Guarcello, V., Mattison, L.K., Fridley, B.L., Diasio, R.B. Pharmacogenet. Genomics (2007) [Pubmed]
  21. Thermostable N-carbamoyl-D-amino acid amidohydrolase: screening, purification and characterization. Ogawa, J., Chung, M.C., Hida, S., Yamada, H., Shimizu, S. J. Biotechnol. (1994) [Pubmed]
  22. Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation. van Gennip, A.H., Busch, S., Elzinga, L., Stroomer, A.E., van Cruchten, A., Scholten, E.G., Abeling, N.G. Clin. Chem. (1993) [Pubmed]
  23. Crystallization and preliminary X-ray analysis of a hydantoinase from Arthrobacter aurescens DSM 3745. May, O., Siemann, M., Syldatk, C., Niefind, C., Schomburg, D. Acta Crystallogr. D Biol. Crystallogr. (1996) [Pubmed]
  24. Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastase. Kushi, H., Miki, T., Nakahara, J., Okamoto, K., Saito, T., Tanjoh, K. Blood Purif. (2006) [Pubmed]
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