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Gene Review

Dpys  -  dihydropyrimidinase

Mus musculus

Synonyms: 1200017I10Rik, 1300004I01Rik, DHP, DHPase, Dihydropyrimidinase, ...
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Psychiatry related information on Dpys

  • These results indicate that DHP calcium channels (type L-channel) play a role in some of the pharmacological effects of nicotine, particularly, locomotor activity and antinociception [1].

High impact information on Dpys

  • Altered inactivation of Ca2+ current and Ca2+ release in mouse muscle fibers deficient in the DHP receptor gamma1 subunit [2].
  • The second class could only be well resolved in the presence of the DHP agonist Bay K 8644 (5 microM) and had a single-channel conductance of approximately 14 pS (L current) [3].
  • 7. The above results show that part of the intramembrane charge movement in Purkinje cells may be related to a conformational change of DHP receptors upon membrane depolarization [4].
  • We also report that the specific protein carbonyl levels of LDH-2, dihydropyrimidinase-like protein 2, alpha-spectrin and creatine kinase, are significantly increased in the brain of 12-month-old SAMP8 mice when compared with the 4-month-old SAMP8 brain [5].
  • All GABA-ergic stimulants used, i.e., gamma-hydroxybutyric acid (GHBA/250 mg/kg), baclofen (2.5 and 10 mg/kg) and aminooxoacetic acid (AOAA; 15 and 20 mg/kg) potentiated the action of PB; the action of DHP was unaffected by these drugs except for AOAA (20 mg/kg) [6].

Biological context of Dpys


Anatomical context of Dpys

  • Recent molecular work has shown that hypoPP is due to mutations in a skeletal muscle voltage-gated calcium channel: the dihydropyridine receptor (DHP receptor) [8].
  • Chronic treatment of mice with DHP, as with 6-methyl thiouracil, increased the avidity of the thyroid in taking up 125I [9].
  • No marked histological changes were found in other organs of mice fed DHP or any organs of mice fed mimosine, except for some atrophy of hair follicles [9].

Associations of Dpys with chemical compounds

  • The L-type Ca(2+) channel (dihydropyridine receptor, DHP receptor) is a central component of the EC coupling process [10].
  • Divalent cations, such as magnesium or manganese, which normally block the physiological effects of calcium, also enhance DHP-receptor binding [11].


  1. Calcium agonists and antagonists of the dihydropyridine type: effect on nicotine-induced antinociception and hypomotility. Damaj, M.I., Martin, B.R. Drug and alcohol dependence. (1993) [Pubmed]
  2. Altered inactivation of Ca2+ current and Ca2+ release in mouse muscle fibers deficient in the DHP receptor gamma1 subunit. Ursu, D., Schuhmeier, R.P., Freichel, M., Flockerzi, V., Melzer, W. J. Gen. Physiol. (2004) [Pubmed]
  3. Single calcium channel behavior in native skeletal muscle. Dirksen, R.T., Beam, K.G. J. Gen. Physiol. (1995) [Pubmed]
  4. Nifedipine-sensitive intramembrane charge movement in Purkinje cells from mouse cerebellum. Melliti, K., Bournaud, R., Bastide, B., Shimahara, T. J. Physiol. (Lond.) (1996) [Pubmed]
  5. Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain. Poon, H.F., Castegna, A., Farr, S.A., Thongboonkerd, V., Lynn, B.C., Banks, W.A., Morley, J.E., Klein, J.B., Butterfield, D.A. Neuroscience (2004) [Pubmed]
  6. Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice. Kleinrok, Z., Czuczwar, S.J., Kozicka, M. Epilepsia (1980) [Pubmed]
  7. Control of expression of the 1,4-dihydropyridine receptor in BC3H1 cells. Rampe, D., Caffrey, J.M., Schneider, M.D., Brown, A.M. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  8. Hypokalemic periodic paralysis: an autosomal dominant muscle disorder caused by mutations in a voltage-gated calcium channel. Lapie, P., Lory, P., Fontaine, B. Neuromuscul. Disord. (1997) [Pubmed]
  9. The goitrogen 3-hydroxy-4(1H)-pyridone, a ruminal metabolite from Leucaena leucocephala: effects in mice and rats. Hegarty, M.P., Lee, C.P., Christie, G.S., Court, R.D., Haydock, K.P. Aust. J. Biol. Sci. (1979) [Pubmed]
  10. Functional roles of the gamma subunit of the skeletal muscle DHP-receptor. Melzer, W., Andronache, Z., Ursu, D. J. Muscle Res. Cell. Motil. (2006) [Pubmed]
  11. In vitro and in vivo effects of lead on specific 3H-PN200-110 binding to dihydropyridine receptors in the frontal cortex of the mouse brain. Schulte, S., Müller, W.E., Friedberg, K.D. Toxicology (1995) [Pubmed]
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