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Gene Review

klc-1  -  Protein KLC-1

Caenorhabditis elegans

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High impact information on kinesin

  • Here we show that the Caenorhabditis elegans kinesin-related protein VAB-8L, which is necessary and sufficient for posterior cell and growth-cone migrations, directs these migrations by regulating the levels of the guidance receptor SAX-3 (also known as robo) [1].
  • Members of the MKLP1 subfamily of kinesin motor proteins localize to the equatorial region of the spindle midzone and are capable of bundling antiparallel microtubules in vitro [2].
  • Using the cho-1 promoter to drive expression of a translational, green fluorescent protein-CHO-1 fusion (CHO-1:GFP) in wild-type and kinesin (unc-104) mutant backgrounds, we establish in the living nematode that the transporter localizes to cholinergic synapses, and likely traffics on synaptic vesicles [3].
  • Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension [4].


  1. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations. Watari-Goshima, N., Ogura, K., Wolf, F.W., Goshima, Y., Garriga, G. Nat. Neurosci. (2007) [Pubmed]
  2. Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4. Raich, W.B., Moran, A.N., Rothman, J.H., Hardin, J. Mol. Biol. Cell (1998) [Pubmed]
  3. The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. Matthies, D.S., Fleming, P.A., Wilkes, D.M., Blakely, R.D. J. Neurosci. (2006) [Pubmed]
  4. Regulators of kinesin involved in polarized trafficking and axon outgrowth. Luo, S., Nonet, M.L. J. Biol. (2006) [Pubmed]
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