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Gene Review

hsp-16.2  -  Protein HSP-16.2

Caenorhabditis elegans

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High impact information on hsp-16.2

  • DNA sites corresponding to both motifs are shown to play a significant role in up-regulation of the hsp-16-2 gene on HS [1].
  • The role of the identified DNA sites in regulation of HS genes was tested by in vitro mutagenesis of a green fluorescent protein (GFP) reporter transgene driven by the C. elegans hsp-16-2 promoter [1].
  • The two genes, designated hsp16-2 and hsp16-41, are arranged in divergent orientations, and each contains a single intron of 46 and 58 base pairs, respectively [2].
  • Comparisons of the derived amino acid sequences show that hsp16-1 and hsp16-2 form a closely related pair, as do hsp16-41 and hsp16-48 [3].
  • Thus, we interpret the suppression of hsp-16-2/GFP expression as an indication that EGb 761 decreases cellular stress resulting from exogenous treatments, therefore leading to a decreased transcriptional induction of the reporter transgene [4].

Biological context of hsp-16.2

  • In this study, the molecular mechanism of EGb 761 on alleviating effects of oxidative stress is further investigated using transgenic C. elegans expressing a jellyfish green fluorescent protein (GFP)-tagged inducible small heat-shock protein gene (hsp-16-2) [4].

Associations of hsp-16.2 with chemical compounds

  • The expression of hsp-16-2 induced by the pro-oxidant juglone and by heat shock was significantly suppressed by 86% and 33%, respectively, in the transgenic nematode fed with EGb 761 [4].


  1. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. GuhaThakurta, D., Palomar, L., Stormo, G.D., Tedesco, P., Johnson, T.E., Walker, D.W., Lithgow, G., Kim, S., Link, C.D. Genome Res. (2002) [Pubmed]
  2. Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements. Jones, D., Russnak, R.H., Kay, R.J., Candido, E.P. J. Biol. Chem. (1986) [Pubmed]
  3. Structure, organization, and expression of the 16-kDa heat shock gene family of Caenorhabditis elegans. Candido, E.P., Jones, D., Dixon, D.K., Graham, R.W., Russnak, R.H., Kay, R.J. Genome (1989) [Pubmed]
  4. Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. Strayer, A., Wu, Z., Christen, Y., Link, C.D., Luo, Y. FASEB J. (2003) [Pubmed]
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