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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gsnl-1  -  Protein GSNL-1

Caenorhabditis elegans

 
 
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High impact information on gelsolin

  • In these highly conserved genes, two previously known gene families have been brought together, families encoding the actin-binding proteins related to gelsolin and the leucine-rich-repeat (LRR) group of proteins involved in protein-protein interactions [1].
  • Some of the residues considered essential for actin and calcium binding in gelsolin S1 and villin V1 are also well conserved [2].
  • The gene encodes a single transcript encoding a protein consisting of a leucine-rich amino terminal half and a carboxyterminal half with high sequence similarity to gelsolin [2].
 

Biological context of gelsolin

References

  1. The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transduction. Claudianos, C., Campbell, H.D. Mol. Biol. Evol. (1995) [Pubmed]
  2. Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster. de Couet, H.G., Fong, K.S., Weeds, A.G., McLaughlin, P.J., Miklos, G.L. Genetics (1995) [Pubmed]
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