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Gene Review

odr-3  -  Protein ODR-3

Caenorhabditis elegans

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High impact information on odr-3

  • Either overexpression of the C. elegans Galpha subunit odr-3 or loss of eat-16, which encodes a regulator of G protein signaling (RGS) protein, restores chemosensation in Ce-grk-2 mutants [1].
  • We show that the G-protein ODR-3 plays an important role in chemosensory avoidance behaviour and identify orthologues of odr-3 in C. briggsae and C. remanei [2].
  • Both quantitative genetic analysis of chemosensory behaviour and molecular population genetic analysis of odr-3 show that there is little genetic variation among a worldwide collection of isolates of the primarily selfing C. elegans, whereas there is substantially more variation within a single population of the outcrossing C. remanei [2].
  • Although there are a large number of substitutions at silent sites within odr-3 among the three species, molecular evolution at the protein level is extremely conserved, suggesting that odr-3 plays an important role in cell signalling during chemosensation and/or neuronal cilia development in C. remanei and in C. briggsae as it does in C. elegans [2].


  1. G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R., Hart, A.C. Neuron (2004) [Pubmed]
  2. Molecular evolution and quantitative variation for chemosensory behaviour in the nematode genus Caenorhabditis. Jovelin, R., Ajie, B.C., Phillips, P.C. Mol. Ecol. (2003) [Pubmed]
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