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Gene Review

gpa-2  -  Protein GPA-2

Caenorhabditis elegans

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Psychiatry related information on gpa-2

  • Interactions between gpa-2, gpa-3 and other genes controlling dauer formation suggest that these G proteins may act in parallel to regulate the neuronal decision making that precedes dauer formation [1].

High impact information on gpa-2

  • We investigated a TA target site from the gpa-2 gene of C.elegans that was previously found to be preferred (hot) for Tc1 integration in vivo . This site with its immediate flanks was cloned into a plasmid, and remained hot in vitro , showing that sequences immediately adjacent to the TA dinucleotide determine this target choice [2].
  • Two G protein alpha subunit genes orthologous to gpa-2 and gpa-3 in Caenorhabditis elegans have been identified in the parasitic nematode, Strongyloides stercoralis [3].

Biological context of gpa-2


  1. Two neuronal G proteins are involved in chemosensation of the Caenorhabditis elegans Dauer-inducing pheromone. Zwaal, R.R., Mendel, J.E., Sternberg, P.W., Plasterk, R.H. Genetics (1997) [Pubmed]
  2. Target choice determinants of the Tc1 transposon of Caenorhabditis elegans. Ketting, R.F., Fischer, S.E., Plasterk, R.H. Nucleic Acids Res. (1997) [Pubmed]
  3. PCR amplification of putative gpa-2 and gpa-3 orthologs from the (A+T)-rich genome of Strongyloides stercoralis. Massey, H.C., Ball, C.C., Lok, J.B. Int. J. Parasitol. (2001) [Pubmed]
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