Disease relevance of Evolution, Molecular

• The molecular evolution of Neisseria gonorrhoeae seems to be driven by the simultaneous action of selection and recombination, but under different rates and selection pressures for the PIA and PIB homology groups [1].
• The molecular evolution of bacterial alkaline phosphatase: correlating variation among enteric bacteria to experimental manipulations of the protein [2].
• Molecular evolution of the Escherichia coli chromosome. V. Recombination patterns among strains of diverse origin [3].
• The molecular evolution of dotA, which is related to the virulence of Legionella pneumophila, was investigated by comparing the sequences of 15 reference strains (serogroups 1 to 15) [4].
• Therefore, the difference in the SQDG requirement for PSII is species-specific in cyanobacteria; this could be of use when investigating the molecular evolution of the PSII complex [5].

High impact information on Evolution, Molecular

• Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity [6].
• We have traced the rapid molecular evolution of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), two host defense proteins that are members of the mammalian ribonuclease gene family [7].
• Molecular evolution of FOXP2, a gene involved in speech and language [8].
• We have tested mutagenic DNA shuffling for molecular evolution in a beta-lactamase model system [9].
• This novel chimeric gene, jingwei, differs from its parent Adh gene in both its pattern of expression and rate of molecular evolution [10].

Chemical compound and disease context of Evolution, Molecular

• Molecular evolution of the Escherichia coli chromosome. I. Analysis of structure and natural variation in a previously uncharacterized region between trp and tonB [11].
• Secrets of success of a human pathogen: molecular evolution of pandemic clones of meticillin-resistant Staphylococcus aureus [12].

Biological context of Evolution, Molecular

• Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner [13].
• The Na(+)-induced allosteric regulation also bears on the molecular evolution of serine proteases [14].
• The alpha-actinin family provides a fascinating case study in molecular evolution, illustrating phenomena such as functional redundancy in duplicate genes, the evolution of protein function, and the action of natural selection during recent human evolution [15].
• A group II intron in the Neurospora mitochondrial coI gene: nucleotide sequence and implications for splicing and molecular evolution [16].
• The average levels of nucleotide divergence were not significantly different across the chromosomes, although both silent and intron sites show a trend toward slightly more divergence on the X. These results indicate a lack of sex- or chromosome-biased molecular evolution in D. melanogaster and D. simulans [17].

Anatomical context of Evolution, Molecular

• Here we examine the molecular evolution of the semenogelin genes (SEMG1 and SEMG2), which code for the predominant structural proteins in human semen [18].
• The high expression of the HNK-1/L2 epitope in glycoproteins of shark myelin, including the major P0-related ones, suggests that this adhesion-related carbohydrate structure may have had an important role in the molecular evolution of the myelinating process [19].
• Membranes from triacylglycerol producing cells in plants and humans may have similar binding sites for acylation stimulating protein which have been preserved during molecular evolution [20].
• Genes for mast-cell serine protease and their molecular evolution [21].
• In spite of this molecular evolution, it is shown that murine beta 2-microglobulin can effect the expression of HLA class I antigens on the surface of human-mouse hybrid cells and that the tertiary structures of human and equine deoxyhemoglobin are nearly identical [22].

Associations of Evolution, Molecular with chemical compounds

• Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution [23].
• Isolation of serine protease genes from organisms of widely diverged phylogenetic groups would provide a basis for studying their biological function, the relationship between structure and function, and the molecular evolution of these enzymes [24].
• In addition, an additional mechanism was acquired in vertebrate rhodopsin to prevent completely the binding of exogenous all-trans-retinal during molecular evolution [25].
• Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells [26].
• Molecular evolution of integrins: genes encoding integrin beta subunits from a coral and a sponge [27].

Gene context of Evolution, Molecular

• The molecular evolution of DAX1, SRY, and SOX9, genes involved in mammalian sex determination, was examined in six primate species [28].
• To facilitate mutation detection and to improve our understanding of the molecular evolution of Phk subunit isoforms, we have determined the structure of the human PHKG2 gene [29].
• Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family [30].
• These Y' and X' boxes have been conserved during the molecular evolution of both human HLA-DRA and murine EA genes [31].
• Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci [32].

Analytical, diagnostic and therapeutic context of Evolution, Molecular

• To study the molecular evolution of flagellin, the protein subunit specifying flagellar (H) antigens, the fliC genes from 15 pathogenic strains of Escherichia coli were amplified by PCR and sequenced [33].
• The variable domains of a triazine-selective single-chain Fv (scFv) were genetically engineered by stringent molecular evolution in order to optimize analytical characteristics of the corresponding atrazine immunoassay [34].
• As part of a wider study on the molecular evolution of alanine:glyoxylate aminotransferase 1 (AGT1) intracellular compartmentalization, we have determined the subcellular distribution of immunoreactive AGT1, using postembedding protein A-gold immunoelectron microscopy, in the livers of various members of the classes Mammalia, Aves, and Amphibia [35].

References