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Gene Review:

gar-3 - Protein GAR-3

Caenorhabditis elegans

Park, Y.S. et al., Steger, K.A. et al., Park, Y.S. et al.

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High impact information on gar-3

GAR-3 signaling is enhanced in worms overexpressing gar-3 or lacking GPB-2, a G-protein beta-subunit involved in RGS-mediated inhibition of G(o)alpha- and G(q)alpha-linked pathways [1].
Loss of gar-3 function results in shortened action potentials and brief muscle contractions in the pharyngeal terminal bulb [1].
Stimulation of cyclic AMP production by the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells [2].
The gar-3 gene, unlike mammalian mAChR genes, contains introns within the coding region [3].
Alternative splicing of the muscarinic acetylcholine receptor GAR-3 in Caenorhabditis elegans [3].

References

The GAR-3 muscarinic receptor cooperates with calcium signals to regulate muscle contraction in the Caenorhabditis elegans pharynx. Steger, K.A., Avery, L. Genetics (2004) [Pubmed]
Stimulation of cyclic AMP production by the Caenorhabditis elegans muscarinic acetylcholine receptor GAR-3 in Chinese hamster ovary cells. Park, Y.S., Cho, T.J., Cho, N.J. Arch. Biochem. Biophys. (2006) [Pubmed]
Alternative splicing of the muscarinic acetylcholine receptor GAR-3 in Caenorhabditis elegans. Park, Y.S., Kim, S., Shin, Y., Choi, B., Cho, N.J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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GPRMAC1	Anopheles gambiae str. PEST
CHRM1	Bos taurus
CHRM1	Canis lupus familiaris
mAChR-A	Drosophila melanogaster
CHRM1	Homo sapiens
CHRM1	Macaca mulatta
Chrm1	Mus musculus
CHRM1	Pan troglodytes
Chrm1	Rattus norvegicus
LOC100490434	Xenopus (Silurana) tropicalis

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