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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-112  -  Protein UNC-112

Caenorhabditis elegans

 
 
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High impact information on unc-112

  • This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes [1].
  • Function of pat-4/integrin-linked kinase (ILK) and unc-112/Mig-2 was examined using RNA-mediated interference (RNAi) [2].
  • In contrast, a missense mutation in unc-112 results in viable animals that have disorganized bodywall muscle and are paralyzed as adults [3].
 

Anatomical context of unc-112

References

  1. The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. Rogalski, T.M., Mullen, G.P., Gilbert, M.M., Williams, B.D., Moerman, D.G. J. Cell Biol. (2000) [Pubmed]
  2. pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans. Xu, X., Rongali, S.C., Miles, J.P., Lee, K.D., Lee, M. Exp. Cell Res. (2006) [Pubmed]
  3. DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity. Rogalski, T.M., Gilbert, M.M., Devenport, D., Norman, K.R., Moerman, D.G. Genetics (2003) [Pubmed]
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