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Gene Review

FERMT2  -  fermitin family member 2

Homo sapiens

Synonyms: Fermitin family homolog 2, KIND2, Kindlin-2, MIG-2, MIG2, ...
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Disease relevance of PLEKHC1

  • These findings suggest that mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus [1].
  • In contrast, the mig-2 expression was greatly decreased in leiomyosarcomas [1].
  • Examination of 30 frozen breast tumors supported the finding that MIG2 is overexpressed in a subset of breast cancers [2].

High impact information on PLEKHC1


Chemical compound and disease context of PLEKHC1

  • Although all 21 normal tissues from reduction mammoplasty showed immunoreactivity for MIG2, ranging from weak (62%) to strong (24%), only half of the 34 formalin-fixed breast tumors showed immunoreactivity for MIG2 [2].

Biological context of PLEKHC1


Anatomical context of PLEKHC1

  • In this study, we investigated the role of ILK, and its binding partners PINCH, alpha-parvin, and Mig-2 in matrix-induced hepatocyte differentiation [7].
  • Using real-time reverse transcription-PCR, we found that mitogen-inducible gene 2 (MIG2) is expressed at a 17-fold higher level in TMX2-28 cells than in nonaggressive MCF-7 cells and that MIG2 mRNA levels are low in the nontumorigenic human mammary epithelial cell line, 184 [2].

Other interactions of PLEKHC1

  • We have also isolated the full-length clones for another novel related gene, URP2 and the previously discovered MIG-2 gene [6].
  • We also show that ILK, PINCH, alpha-parvin, and Mig-2 expression level is dramatically reduced in the re-differentiated hepatocytes [7].

Analytical, diagnostic and therapeutic context of PLEKHC1


  1. Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas. Kato, K., Shiozawa, T., Mitsushita, J., Toda, A., Horiuchi, A., Nikaido, T., Fujii, S., Konishi, I. Hum. Pathol. (2004) [Pubmed]
  2. Use of an Aggressive MCF-7 Cell Line Variant, TMX2-28, to Study Cell Invasion in Breast Cancer. Gozgit, J.M., Pentecost, B.T., Marconi, S.A., Otis, C.N., Wu, C., Arcaro, K.F. Mol. Cancer Res. (2006) [Pubmed]
  3. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Tu, Y., Wu, S., Shi, X., Chen, K., Wu, C. Cell (2003) [Pubmed]
  4. The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane. Rogalski, T.M., Mullen, G.P., Gilbert, M.M., Williams, B.D., Moerman, D.G. J. Cell Biol. (2000) [Pubmed]
  5. The Kindlins: Subcellular localization and expression during murine development. Ussar, S., Wang, H.V., Linder, S., Fässler, R., Moser, M. Exp. Cell Res. (2006) [Pubmed]
  6. URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas. Weinstein, E.J., Bourner, M., Head, R., Zakeri, H., Bauer, C., Mazzarella, R. Biochim. Biophys. Acta (2003) [Pubmed]
  7. Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Gkretsi, V., Bowen, W.C., Yang, Y., Wu, C., Michalopoulos, G.K. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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