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Gene Review:

num-1 - Protein NUM-1

Caenorhabditis elegans

Zhang, L. et al., Zhang, L. et al.

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High impact information on num-1

Phosphorylation site domains (PSD1, residues 11-25; PSD2, residues 61-77) in CKA1 route the adapter (and tethered PKC3) to the cell periphery [1].
Transfection experiments demonstrated that CKA1/CKA1S sequesters PKC3 in intact cells [2].
A distinct, Arg/Lys-rich N-terminal region targets CKA1 to the cell periphery [1].
Structural information in CKA1/CKA1S enables delivery of adapters to the lateral plasma membrane surface (near tight junctions) in polarized epithelial cells [2].

References

Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. Zhang, L., Wu, S.L., Rubin, C.S. J. Biol. Chem. (2001) [Pubmed]
A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. Zhang, L., Wu, S.L., Rubin, C.S. J. Biol. Chem. (2001) [Pubmed]

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