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MeSH Review

Tight Junctions

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Disease relevance of Tight Junctions


Psychiatry related information on Tight Junctions


High impact information on Tight Junctions

  • Here, we report that virus attachment to DAF on the apical cell surface activates Abl kinase, triggering Rac-dependent actin rearrangements that permit virus movement to the tight junction [7].
  • Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29 [8].
  • The claudin family of genes is known to express protein components of tight junctions in other tissues [8].
  • Our results demonstrate that OSP is the mediator of parallel-array tight junction strands and distinguishes this protein from other intrinsic membrane proteins in tight junctions [9].
  • These novel results provide direct evidence of the pivotal role of the claudin family in generating the paracellular physical barrier of tight junctions necessary for spermatogenesis and normal CNS function [9].

Chemical compound and disease context of Tight Junctions


Biological context of Tight Junctions


Anatomical context of Tight Junctions


Associations of Tight Junctions with chemical compounds

  • The luminal clefts, which permit free inward diffusion of tracers, present no tight junctions, but do have septate junctions [24].
  • Tight junctions, membrane-associated guanylate kinases and cell signaling [25].
  • Permeability of paracellular shunt pathways is increase by transmucosal osmotic gradients, and in certain epithelia these changes are associated with bullous-like deformations (blisters) of the zonula occludens and localization of lanthanum within junctional complexes [26].
  • We have previously shown that Na(+)-coupled transport of glucose and amino acids across the apical membrane of intestinal absorptive cells is accompanied by alterations in cytoskeletal structure and altered sieving of small hydrophilic solutes by tight junctions [27].
  • Under control situations ruthenium red penetrated less than 10% of the tight junctions [2].

Gene context of Tight Junctions


Analytical, diagnostic and therapeutic context of Tight Junctions


  1. Claudins in occluding junctions of humans and flies. Furuse, M., Tsukita, S. Trends Cell Biol. (2006) [Pubmed]
  2. Ischemia-induced loss of epithelial polarity. Role of the tight junction. Molitoris, B.A., Falk, S.A., Dahl, R.H. J. Clin. Invest. (1989) [Pubmed]
  3. Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Hadj-Rabia, S., Baala, L., Vabres, P., Hamel-Teillac, D., Jacquemin, E., Fabre, M., Lyonnet, S., De Prost, Y., Munnich, A., Hadchouel, M., Smahi, A. Gastroenterology (2004) [Pubmed]
  4. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  5. Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis. Kawaguchi, T., Sakisaka, S., Mitsuyama, K., Harada, M., Koga, H., Taniguchi, E., Sasatomi, K., Kimura, R., Ueno, T., Sawada, N., Mori, M., Sata, M. Hepatology (2000) [Pubmed]
  6. Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia. Boven, L.A., Middel, J., Verhoef, J., De Groot, C.J., Nottet, H.S. Neuropathol. Appl. Neurobiol. (2000) [Pubmed]
  7. Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Coyne, C.B., Bergelson, J.M. Cell (2006) [Pubmed]
  8. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Wilcox, E.R., Burton, Q.L., Naz, S., Riazuddin, S., Smith, T.N., Ploplis, B., Belyantseva, I., Ben-Yosef, T., Liburd, N.A., Morell, R.J., Kachar, B., Wu, D.K., Griffith, A.J., Riazuddin, S., Friedman, T.B. Cell (2001) [Pubmed]
  9. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Gow, A., Southwood, C.M., Li, J.S., Pariali, M., Riordan, G.P., Brodie, S.E., Danias, J., Bronstein, J.M., Kachar, B., Lazzarini, R.A. Cell (1999) [Pubmed]
  10. The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1. Kurihara, H., Anderson, J.M., Kerjaschki, D., Farquhar, M.G. Am. J. Pathol. (1992) [Pubmed]
  11. Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease. Söderholm, J.D., Olaison, G., Peterson, K.H., Franzén, L.E., Lindmark, T., Wirén, M., Tagesson, C., Sjödahl, R. Gut (2002) [Pubmed]
  12. The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. Nava, P., López, S., Arias, C.F., Islas, S., González-Mariscal, L. J. Cell. Sci. (2004) [Pubmed]
  13. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Rao, R.K., Seth, A., Sheth, P. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  14. The isoflavone genistein inhibits internalization of enteric bacteria by cultured Caco-2 and HT-29 enterocytes. Wells, C.L., Jechorek, R.P., Kinneberg, K.M., Debol, S.M., Erlandsen, S.L. J. Nutr. (1999) [Pubmed]
  15. Regulation of Par6 by extracellular signals. Bose, R., Wrana, J.L. Curr. Opin. Cell Biol. (2006) [Pubmed]
  16. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Gudjonsson, T., Villadsen, R., Nielsen, H.L., Rønnov-Jessen, L., Bissell, M.J., Petersen, O.W. Genes Dev. (2002) [Pubmed]
  17. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. El Asmar, R., Panigrahi, P., Bamford, P., Berti, I., Not, T., Coppa, G.V., Catassi, C., Fasano, A., El Asmar, R. Gastroenterology (2002) [Pubmed]
  18. Possible involvement of phosphorylation of occludin in tight junction formation. Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y., Tsukita, S. J. Cell Biol. (1997) [Pubmed]
  19. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., Tsukita, S. J. Cell Biol. (2003) [Pubmed]
  20. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Lee, S.W., Kim, W.J., Choi, Y.K., Song, H.S., Son, M.J., Gelman, I.H., Kim, Y.J., Kim, K.W. Nat. Med. (2003) [Pubmed]
  21. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Chen, X., Macara, I.G. Nat. Cell Biol. (2005) [Pubmed]
  22. Structural diversity of occluding junctions in the low-resistance chloride-secreting opercular epithelium of seawater-adapted killifish (Fundulus heteroclitus). Ernst, S.A., Dodson, W.C., Karnaky, K.J. J. Cell Biol. (1980) [Pubmed]
  23. alpha-Actinin localization in the junctional complex of intestinal epithelial cells. Craig, S.W., Pardo, J.V. J. Cell Biol. (1979) [Pubmed]
  24. Tight junctions in a fluid-transporting epithelium of an insect. Lane, N.J. Science (1979) [Pubmed]
  25. Tight junctions, membrane-associated guanylate kinases and cell signaling. Kim, S.K. Curr. Opin. Cell Biol. (1995) [Pubmed]
  26. Bile formation in the rat: the role of the paracellular shunt pathway. Layden, T.J., Elias, E., Boyer, J.L. J. Clin. Invest. (1978) [Pubmed]
  27. Supraphysiologic L-tryptophan elicits cytoskeletal and macromolecular permeability alterations in hamster small intestinal epithelium in vitro. Madara, J.L., Carlson, S. J. Clin. Invest. (1991) [Pubmed]
  28. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Bilder, D., Perrimon, N. Nature (2000) [Pubmed]
  29. Human hypertension caused by mutations in WNK kinases. Wilson, F.H., Disse-Nicodème, S., Choate, K.A., Ishikawa, K., Nelson-Williams, C., Desitter, I., Gunel, M., Milford, D.V., Lipkin, G.W., Achard, J.M., Feely, M.P., Dussol, B., Berland, Y., Unwin, R.J., Mayan, H., Simon, D.B., Farfel, Z., Jeunemaitre, X., Lifton, R.P. Science (2001) [Pubmed]
  30. Complex redundancy to build a simple epidermal permeability barrier. Segre, J. Curr. Opin. Cell Biol. (2003) [Pubmed]
  31. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Hurd, T.W., Gao, L., Roh, M.H., Macara, I.G., Margolis, B. Nat. Cell Biol. (2003) [Pubmed]
  32. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Madsen, K.L., Lewis, S.A., Tavernini, M.M., Hibbard, J., Fedorak, R.N. Gastroenterology (1997) [Pubmed]
  33. Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas. Fallon, M.B., Gorelick, F.S., Anderson, J.M., Mennone, A., Saluja, A., Steer, M.L. Gastroenterology (1995) [Pubmed]
  34. Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Walsh, S.V., Hopkins, A.M., Chen, J., Narumiya, S., Parkos, C.A., Nusrat, A. Gastroenterology (2001) [Pubmed]
  35. An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations. Implications for oligopeptide absorption. Atisook, K., Madara, J.L. Gastroenterology (1991) [Pubmed]
  36. COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. Chen, Y., Merzdorf, C., Paul, D.L., Goodenough, D.A. J. Cell Biol. (1997) [Pubmed]
  37. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Schmitt, M., Kubitz, R., Lizun, S., Wettstein, M., Häussinger, D. Hepatology (2001) [Pubmed]
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