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Gene Review

ncs-1  -  Protein NCS-1

Caenorhabditis elegans

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High impact information on ncs-1

  • Thus, proper calcium signaling via NCS-1 defines a novel pathway essential for associative learning and memory [1].
  • The knockout phenotype can be rescued by reintroducing wild-type NCS-1 into the AIY interneuron, a key component of the thermotaxis network [1].
  • Increased temperature-food association of the daf-2 mutant was dependent on neuronal Ca2+-sensor ncs-1, which modulates isothermal tracking in the AIY interneuron [2].


  1. Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., Bartfai, T., Bargmann, C.I., Nef, P. Neuron (2001) [Pubmed]
  2. Aging-dependent and -independent modulation of associative learning behavior by insulin/insulin-like growth factor-1 signal in Caenorhabditis elegans. Murakami, H., Bessinger, K., Hellmann, J., Murakami, S. J. Neurosci. (2005) [Pubmed]
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