Gene Review:
rme-6 - Protein RME-6
Caenorhabditis elegans
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High impact information on rme-6
- Consistent with the known catalytic function of Vps9 domains in Rab5 GDP/GTP exchange, we found that RME-6 binds specifically to Caenorhabditis elegans RAB-5 in the GDP-bound conformation, and rme-6 mutants have phenotypes that indicate low RAB-5 activity [1].
- In rme-6 mutants, transport from the plasma membrane to endosomes is defective, and small 110-nm endocytic vesicles accumulate just below the plasma membrane [1].
References
- Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit. Sato, M., Sato, K., Fonarev, P., Huang, C.J., Liou, W., Grant, B.D. Nat. Cell Biol. (2005) [Pubmed]
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