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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lin-18  -  Protein LIN-18

Caenorhabditis elegans

 
 
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High impact information on lin-18

  • In Caenorhabditis elegans, mutations in lin-17, a Frizzled-class Wnt receptor, and in lin-18 affect cell fate patterning in the P7.p vulval lineage [1].
  • We found that lin-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors [1].
 

Anatomical context of lin-18

  • We demonstrate that lin-17 (Frizzled type Wnt receptor) and lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva [2].

References

  1. C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Inoue, T., Oz, H.S., Wiland, D., Gharib, S., Deshpande, R., Hill, R.J., Katz, W.S., Sternberg, P.W. Cell (2004) [Pubmed]
  2. lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development. Deshpande, R., Inoue, T., Priess, J.R., Hill, R.J. Dev. Biol. (2005) [Pubmed]
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