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Gene Review:

Ryk - receptor-like tyrosine kinase

Rattus norvegicus

Califano, D. et al., Squinto, S.P. et al., Califano, D. et al.

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High impact information on Ryk

However, both BDNF and NT-3, but not NGF, bind to full-length and truncated forms of a receptor-like tyrosine kinase, trkB, for which no ligand had previously been identified [1].
Germ-line missense mutations of the receptor-like tyrosine kinase ret are the causative genetic event of the multiple endocrine neoplasia (MEN) type 2A and type 2B syndromes and of the familial medullary thyroid carcinoma [2].
The expression of the receptor-like tyrosine kinase RET is associated with tumors, tissues or cell lines of neural crest origin [3].

References

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E., Valenzuela, D.M. Cell (1991) [Pubmed]
A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells. Califano, D., D'Alessio, A., Colucci-D'Amato, G.L., De Vita, G., Monaco, C., Santelli, G., Di Fiore, P.P., Vecchio, G., Fusco, A., Santoro, M., de Franciscis, V. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells. Califano, D., Monaco, C., de Vita, G., D'Alessio, A., Dathan, N.A., Possenti, R., Vecchio, G., Fusco, A., Santoro, M., de Franciscis, V. Oncogene (1995) [Pubmed]

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AgaP_AGAP006405	Anopheles gambiae str. PEST
RYK	Bos taurus
lin-18	Caenorhabditis elegans
RYK	Canis lupus familiaris
ryk	Danio rerio
Drl-2	Drosophila melanogaster
RYK	Gallus gallus
RYK	Homo sapiens
Ryk	Mus musculus
RYK	Pan troglodytes
ryk	Xenopus (Silurana) tropicalis

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