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Gene Review

Ryk  -  receptor-like tyrosine kinase

Mus musculus

Synonyms: AW536699, ERK-3, Kinase VIK, Met-related kinase, Mrk, ...
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High impact information on Ryk


Biological context of Ryk

  • Quantitative reduction of Southern blotting stringency for the detection of Ryk-related sequences provided evidence for a retroprocessed mouse pseudogene and a more distantly related gene paralogue [5].
  • Flow cytometric analysis with a monospecific anti-Ryk Ab demonstrates that Ryk+ cells constitute 36.7% and Lin+/Ryk+ cells constitute 33.7% of low density bone marrow cells whereas Ryk+ cells represent only 0.3% of the Lin- population [6].
  • This hypothesis is supported by the multiple developmental phenotypes apparent in Ryk loss-of-function mice [7].

Anatomical context of Ryk

  • Ryk RNA is present at greatly increased levels in cells at particular stages of epithelial differentiation: the basal layer of skin and tongue epithelia, the intervillous layer and some crypt bases of the intestine and the lower matrix region of the hair follicle [8].
  • Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract [9].
  • In summary, this study expands the emerging role for Wnts in axon guidance and identifies Ryk as a key guidance receptor in the establishment of the corpus callosum [10].
  • Recently, Ryk-Wnt interactions were shown to guide corticospinal axons down the embryonic mouse spinal cord [10].
  • Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development [3].

Regulatory relationships of Ryk

  • Recent genetic analyses of mouse Ryk and its Drosophila orthologue derailed have defined a role for this novel subfamily of receptors in the control of craniofacial development and neuronal pathway selection, respectively [11].
  • Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma [8].

Other interactions of Ryk


  1. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Lu, W., Yamamoto, V., Ortega, B., Baltimore, D. Cell (2004) [Pubmed]
  2. Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Halford, M.M., Armes, J., Buchert, M., Meskenaite, V., Grail, D., Hibbs, M.L., Wilks, A.F., Farlie, P.G., Newgreen, D.F., Hovens, C.M., Stacker, S.A. Nat. Genet. (2000) [Pubmed]
  3. Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. DeChiara, T.M., Kimble, R.B., Poueymirou, W.T., Rojas, J., Masiakowski, P., Valenzuela, D.M., Yancopoulos, G.D. Nat. Genet. (2000) [Pubmed]
  4. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Davis, S., Aldrich, T.H., Jones, P.F., Acheson, A., Compton, D.L., Jain, V., Ryan, T.E., Bruno, J., Radziejewski, C., Maisonpierre, P.C., Yancopoulos, G.D. Cell (1996) [Pubmed]
  5. Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk). Halford, M.M., Oates, A.C., Hibbs, M.L., Wilks, A.F., Stacker, S.A. J. Biol. Chem. (1999) [Pubmed]
  6. The receptor tyrosine kinase-related gene (ryk) demonstrates lineage and stage-specific expression in hematopoietic cells. Simoneaux, D.K., Fletcher, F.A., Jurecic, R., Shilling, H.G., Van, N.T., Patel, P., Belmont, J.W. J. Immunol. (1995) [Pubmed]
  7. Ryk: A novel Wnt receptor regulating axon pathfinding. Keeble, T.R., Cooper, H.M. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  8. Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma. Serfas, M.S., Tyner, A.L. Oncogene (1998) [Pubmed]
  9. Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Liu, Y., Shi, J., Lu, C.C., Wang, Z.B., Lyuksyutova, A.I., Song, X.J., Song, X., Zou, Y. Nat. Neurosci. (2005) [Pubmed]
  10. The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. Keeble, T.R., Halford, M.M., Seaman, C., Kee, N., Macheda, M., Anderson, R.B., Stacker, S.A., Cooper, H.M. J. Neurosci. (2006) [Pubmed]
  11. Revelations of the RYK receptor. Halford, M.M., Stacker, S.A. Bioessays (2001) [Pubmed]
  12. Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK. Gough, N.M., Rakar, S., Hovens, C.M., Wilks, A. Mamm. Genome (1995) [Pubmed]
  13. Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. Zhou, R., Copeland, T.D., Kromer, L.F., Schulz, N.T. J. Neurosci. Res. (1994) [Pubmed]
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