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Gene Review

RYK  -  receptor-like tyrosine kinase

Homo sapiens

Synonyms: D3S3195, JTK5, JTK5A, RYK1, Tyrosine-protein kinase RYK
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Disease relevance of RYK

  • A cDNA encoding the human homologue of mouse RYK (related to receptor tyrosine kinases) has been cloned from an interleukin 1 (IL-1)-stimulated human hepatoma cDNA library by cross-species hybridization using the mouse RYK cDNA as a probe [1].
  • H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer [2].
  • A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate [3].

High impact information on RYK


Biological context of RYK


Anatomical context of RYK


Associations of RYK with chemical compounds

  • RYK is an atypical orphan receptor tyrosine kinase that lacks detectable kinase activity [6].

Other interactions of RYK


Analytical, diagnostic and therapeutic context of RYK


  1. Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). Stacker, S.A., Hovens, C.M., Vitali, A., Pritchard, M.A., Baker, E., Sutherland, G.R., Wilks, A.F. Oncogene (1993) [Pubmed]
  2. H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. Wang, X.C., Katso, R., Butler, R., Hanby, A.M., Poulsom, R., Jones, T., Sheer, D., Ganesan, T.S. Mol. Med. (1996) [Pubmed]
  3. A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. Watanabe, A., Akita, S., Tin, N.T., Natsume, N., Nakano, Y., Niikawa, N., Uchiyama, T., Yoshiura, K. Cleft Palate Craniofac. J. (2006) [Pubmed]
  4. Frizzled/RYK mediated signalling in axon guidance. Bovolenta, P., Rodriguez, J., Esteve, P. Development (2006) [Pubmed]
  5. Revelations of the RYK receptor. Halford, M.M., Stacker, S.A. Bioessays (2001) [Pubmed]
  6. RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. Trivier, E., Ganesan, T.S. J. Biol. Chem. (2002) [Pubmed]
  7. Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk). Halford, M.M., Oates, A.C., Hibbs, M.L., Wilks, A.F., Stacker, S.A. J. Biol. Chem. (1999) [Pubmed]
  8. Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK. Gough, N.M., Rakar, S., Hovens, C.M., Wilks, A. Mamm. Genome (1995) [Pubmed]
  9. Sharing of unrelated receptors and ligands by cognate partners: possible implications for ovarian and endometrial physiology. Ben-Shlomo, I. Reprod. Biomed. Online (2005) [Pubmed]
  10. ICI 182,780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Leung, Y.K., Gao, Y., Lau, K.M., Zhang, X., Ho, S.M. Neoplasia (2006) [Pubmed]
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