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Gene Review

tyra-2  -  Protein TYRA-2

Caenorhabditis elegans

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High impact information on tyra-2

  • Other physiologically relevant biogenic amines, such as octopamine and dopamine, inhibit [(3)H]tyramine binding with much lower affinity (K(i)s of 1.55 +/- 0.5 and 1.78 +/- 0.6 microM, respectively), supporting the identification of TYRA-2 as a tyramine receptor [1].
  • Significantly, tyramine reduces forskolin-stimulated cAMP levels in HEK293 cells stably expressing SER-2 with an IC50 of about 360 nm, suggesting that SER-2 is a tyramine receptor [2].


  1. TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons. Rex, E., Hapiak, V., Hobson, R., Smith, K., Xiao, H., Komuniecki, R. J. Neurochem. (2005) [Pubmed]
  2. Characterization of a tyramine receptor from Caenorhabditis elegans. Rex, E., Komuniecki, R.W. J. Neurochem. (2002) [Pubmed]
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