The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

octopamine     4-(2-amino-1-hydroxy- ethyl)phenol

Synonyms: Norphen, Analet, Norden, Norfen, Octapamine, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Norsynephrine


Psychiatry related information on Norsynephrine


High impact information on Norsynephrine


Chemical compound and disease context of Norsynephrine


Biological context of Norsynephrine


Anatomical context of Norsynephrine


Associations of Norsynephrine with other chemical compounds


Gene context of Norsynephrine

  • The preincubation of platelet MAO-B with purified MAO-A from mitochondrial membranes of human placenta resulted in appearance of excess octopamine activity [27].
  • The effect of tyramine but not of octopamine was selectively abolished in the TyrR mutant hono, suggesting that this gene encodes a receptor for tyramine, and not for octopamine [32].
  • To test more specifically what role octopamine plays in the antennal lobe, we used two treatments to disrupt an octopamine receptor from Apis mellifera brain (AmOAR) function: (1) an OAR antagonist, mianserin, was used to block receptor function, and (2) AmOAR double-stranded RNA was used to silence receptor expression [33].
  • T beta h-null flies are octopamine-less but survive to adulthood [34].
  • We previously identified one of the Drosophila octopamine receptors named OAMB that produces increases in cAMP and intracellular Ca2+ upon ligand binding [35].

Analytical, diagnostic and therapeutic context of Norsynephrine


  1. Urinary and serum octopamine in patients with portal-systemic encephalopathy. Manghani, K.K., Lunzer, M.R., Billing, B.H., Sherlock, S. Lancet (1975) [Pubmed]
  2. Characterization of octopamine-sensitive adenylate cyclase: elucidation of a class of potent and selective octopamine-2 receptor agonists with toxic effects in insects. Nathanson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Changes in brain catecholamine levels in human cirrhotic hepatic encephalopathy. Cuilleret, G., Pomier-Layrargues, G., Pons, F., Cadilhac, J., Michel, H. Gut (1980) [Pubmed]
  4. Animal models of osteomyelitis. Mader, J.T. Am. J. Med. (1985) [Pubmed]
  5. Octopamine modulates honey bee dance behavior. Barron, A.B., Maleszka, R., Vander Meer, R.K., Robinson, G.E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  6. Serotonin and octopamine have opposite modulatory effects on the crayfish's lateral giant escape reaction. Glanzman, D.L., Krasne, F.B. J. Neurosci. (1983) [Pubmed]
  7. Octopamine and locomotor activity of rats. Delacour, J., Guenaire, C. Psychopharmacology (Berl.) (1983) [Pubmed]
  8. Blood-brain barrier derangement in uremic encephalopathy. Jeppsson, B., Freund, H.R., Gimmon, Z., James, J.H., von Meyenfeldt, M.F., Fischer, J.E. Surgery (1982) [Pubmed]
  9. Intracerebroventricular administration of octopamine stimulates food intake of chicks through alpha(2)-adrenoceptor. Bungo, T., Higaki, T., Ueda, H., Furuse, M. Physiol. Behav. (2002) [Pubmed]
  10. Octopamine--a neurohormone with presynaptic activity-dependent effects at crayfish neuromuscular junctions. Breen, C.A., Atwood, H.L. Nature (1983) [Pubmed]
  11. Action of formamidine pesticides on octopamine receptors. Evans, P.D., Gee, J.D. Nature (1980) [Pubmed]
  12. Serotonin and octopamine in the nematode Caenorhabditis elegans. Horvitz, H.R., Chalfie, M., Trent, C., Sulston, J.E., Evans, P.D. Science (1982) [Pubmed]
  13. Efferent fibers to Limulus eyes synthesize and release octopamine. Batelle, B.A., Evans, J.A., Chamberlain, S.C. Science (1982) [Pubmed]
  14. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Haller, C.A., Benowitz, N.L., Jacob, P. Am. J. Med. (2005) [Pubmed]
  15. Acute effect of labetalol on blood pressure in relation to the sympathetic nervous system and plasma renin activity. Vlachakis, N.D., Barr, J., Velasquez, M., Alexander, N., Maronde, R. Clin. Pharmacol. Ther. (1984) [Pubmed]
  16. Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths. Kinnamon, S.C., Klaassen, L.W., Kammer, A.E., Claassen, D. J. Neurobiol. (1984) [Pubmed]
  17. Catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO1 via meta cleavage of homoprotocatechuic acid. Cuskey, S.M., Olsen, R.H. J. Bacteriol. (1988) [Pubmed]
  18. Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. Robb, S., Cheek, T.R., Hannan, F.L., Hall, L.M., Midgley, J.M., Evans, P.D. EMBO J. (1994) [Pubmed]
  19. Octopamine enhances dark-adaptation in Limulus ventral photoreceptors. O'Day, P.M., Lisman, J.E. J. Neurosci. (1985) [Pubmed]
  20. Efferent neurotransmission of circadian rhythms in Limulus lateral eye. I. Octopamine-induced increases in retinal sensitivity. Kass, L., Barlow, R.B. J. Neurosci. (1984) [Pubmed]
  21. Serotonin-induced protein phosphorylation in a lobster neuromuscular preparation. Goy, M.F., Schwarz, T.L., Kravitz, E.A. J. Neurosci. (1984) [Pubmed]
  22. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. Feng, G., Hannan, F., Reale, V., Hon, Y.Y., Kousky, C.T., Evans, P.D., Hall, L.M. J. Neurosci. (1996) [Pubmed]
  23. Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Chang, D.J., Li, X.C., Lee, Y.S., Kim, H.K., Kim, U.S., Cho, N.J., Lo, X., Weiss, K.R., Kandel, E.R., Kaang, B.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  24. Neuropeptides, amines and amino acids in an elementary insect ganglion: functional and chemical anatomy of the unfused abdominal ganglion. Nässel, D.R. Prog. Neurobiol. (1996) [Pubmed]
  25. Cellular mechanisms for modulation of posture by octopamine and serotonin in the lobster. Harris-Warrick, R.M., Kravitz, E.A. J. Neurosci. (1984) [Pubmed]
  26. Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility. Cole, S.H., Carney, G.E., McClung, C.A., Willard, S.S., Taylor, B.J., Hirsh, J. J. Biol. Chem. (2005) [Pubmed]
  27. Modification of substrate-inhibitor affinities of human platelet monoamine oxidase B in vitro. Szutowicz, A., Tomaszewicz, M., Orsulak, P.J. J. Biol. Chem. (1989) [Pubmed]
  28. Phenylethanolamine: a new putative neurotransmitter in Aplysia. Saavedra, J.M., Ribas, J., Swann, J., Carpenter, D.O. Science (1977) [Pubmed]
  29. Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Alkema, M.J., Hunter-Ensor, M., Ringstad, N., Horvitz, H.R. Neuron (2005) [Pubmed]
  30. p-Coumaroylnoradrenaline, a novel plant metabolite implicated in tomato defense against pathogens. Von Roepenack-Lahaye, E., Newman, M.A., Schornack, S., Hammond-Kosack, K.E., Lahaye, T., Jones, J.D., Daniels, M.J., Dow, J.M. J. Biol. Chem. (2003) [Pubmed]
  31. Phenyliminoimidazolidines. Characterization of a class of potent agonists of octopamine-sensitive adenylate cyclase and their use in understanding the pharmacology of octopamine receptors. Nathanson, J.A. Mol. Pharmacol. (1985) [Pubmed]
  32. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Nagaya, Y., Kutsukake, M., Chigusa, S.I., Komatsu, A. Neurosci. Lett. (2002) [Pubmed]
  33. Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee. Farooqui, T., Robinson, K., Vaessin, H., Smith, B.H. J. Neurosci. (2003) [Pubmed]
  34. Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine. Monastirioti, M., Linn, C.E., White, K. J. Neurosci. (1996) [Pubmed]
  35. Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster. Lee, H.G., Seong, C.S., Kim, Y.C., Davis, R.L., Han, K.A. Dev. Biol. (2003) [Pubmed]
  36. Stimulation of pheromone biosynthesis in the moth Helicoverpa zea: action of a brain hormone on pheromone glands involves Ca2+ and cAMP as second messengers. Jurenka, R.A., Jacquin, E., Roelofs, W.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  37. Deletions in the genomes of pseudorabies virus vaccine strains and existence of four isomers of the genomes. Lomniczi, B., Blankenship, M.L., Ben-Porat, T. J. Virol. (1984) [Pubmed]
  38. Alterations in brain octopamine and brain tyrosine following portacaval anastomosis in rats. James, J.H., Hodgman, J.M., Funovics, J.M., Fischer, J.E. J. Neurochem. (1976) [Pubmed]
  39. Specific antisera against the catecholamines: L-3,4-dihydroxyphenylalanine, dopamine, noradrenaline, and octopamine tested by an enzyme-linked immunosorbent assay. Mons, N., Geffard, M. J. Neurochem. (1987) [Pubmed]
WikiGenes - Universities