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Gene Review

Htr1b  -  5-hydroxytryptamine (serotonin) receptor 1B

Mus musculus

Synonyms: 5-HT receptor, 5-HT-1B, 5-HT1B, 5-HT1B receptor, 5-hydroxytryptamine receptor 1B, ...
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Disease relevance of Htr1b


Psychiatry related information on Htr1b


High impact information on Htr1b

  • Null mutant mice lacking the 5-HT1B receptor gene (5-HT1B-/-) have been developed that display enhanced aggression and altered 5-HT release in slice preparations from some, but not all, brain areas [9].
  • Our results suggest that the 5-HT1B receptor participates in the regulation of ethanol drinking, and demonstrate that serotonergic manipulations lead to reduced responsiveness to certain ataxic effects of ethanol without affecting dependence [9].
  • Here we examine the effects of cocaine in mice lacking one of the serotonin-receptor subtypes, the 5-HT1B receptor [10].
  • However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors [11].
  • IL-4, IL-13, and 5-HT receptor messenger RNA expressions were determined by real-time quantitative polymerase chain reaction [12].

Chemical compound and disease context of Htr1b


Biological context of Htr1b


Anatomical context of Htr1b

  • (iv) The 5-HT hyperinnervation in the amygdalo-hippocampal nucleus and ventral hippocampus of 5-HT1B KOs could play a role in their increased aggressiveness, and might also explain their better performance in some cognitive tests [17].
  • The 5-HT1F receptor transcript is present in proliferative regions such as the cortical ventricular zone, ganglionic eminences, and medial aspects of the thalamus at E14.5-16.5, and otherwise presents similarities to the expression patterns of 5-HT1B and 1D receptor transcripts [20].
  • Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors [21].
  • The effects of 5-HT receptor activation on optic nerve-mediated input to SCN neurons were examined using whole-cell patch-clamp recordings in horizontal slices of ventral hypothalamus from the male mouse [21].
  • The distribution of 5-HT1B and 5-HT1D receptors in all species examined so far, is very similar: high concentrations of sites are found in the nigro-striatal pathway, caudate-putamen, globus pallidus and especially substantia nigra [22].

Associations of Htr1b with chemical compounds


Physical interactions of Htr1b


Regulatory relationships of Htr1b


Other interactions of Htr1b

  • The regional density of 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2B receptors has been measured in the brains of parental strains, F(1) and F(2) populations by quantitative autoradiography [30].
  • (ii) 5-HTT is down-regulated in several brain regions of 5-HT1A and 5-HT1B KO mice [17].
  • In addition, we show that 5-HT1B receptor KO mice have a lowered hypothalamic c-fos response to the administration of 5-HT2C receptor agonists [31].
  • The nonspecific 5-HT receptor agonist (and 5-HT2 receptor antagonist) quipazine also induced "wet dog shaking" at doses which suppressed aggression, social interest, and exploration but increased inactive behaviors (sitting and lying) [32].
  • PrPC ligation selectively cancels the 5-HT2A-PLC response, decreases the 5-HT1B/D negative coupling to adenylate cyclase, and potentiates the 5-HT2B-PLA2 coupling [27].

Analytical, diagnostic and therapeutic context of Htr1b


  1. The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Goodwin, G.M., De Souza, R.J., Green, A.R. Psychopharmacology (Berl.) (1986) [Pubmed]
  2. Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal. Bouwknecht, J.A., van der Gugten, J., Hijzen, T.H., Maes, R.A., Hen, R., Olivier, B. Psychopharmacology (Berl.) (2001) [Pubmed]
  3. 5-HT1B receptors modulate the feeding inhibitory effects of enterostatin. Lin, L., York, D.A. Brain Res. (2005) [Pubmed]
  4. Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Maroteaux, L., Saudou, F., Amlaiky, N., Boschert, U., Plassat, J.L., Hen, R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5-HT receptor antagonists in a mouse model of allergic asthma. De Bie, J.J., Henricks, P.A., Cruikshank, W.W., Hofman, G., Jonker, E.H., Nijkamp, F.P., Van Oosterhout, A.J. Br. J. Pharmacol. (1998) [Pubmed]
  6. Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice. Boutrel, B., Franc, B., Hen, R., Hamon, M., Adrien, J. J. Neurosci. (1999) [Pubmed]
  7. 3,4-N-methlenedioxymethamphetamine-induced hypophagia is maintained in 5-HT1B receptor knockout mice, but suppressed by the 5-HT2C receptor antagonist RS102221. Conductier, G., Crosson, C., Hen, R., Bockaert, J., Compan, V. Neuropsychopharmacology (2005) [Pubmed]
  8. Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Hain, H.S., Belknap, J.K., Mogil, J.S. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  9. Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Crabbe, J.C., Phillips, T.J., Feller, D.J., Hen, R., Wenger, C.D., Lessov, C.N., Schafer, G.L. Nat. Genet. (1996) [Pubmed]
  10. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Rocha, B.A., Scearce-Levie, K., Lucas, J.J., Hiroi, N., Castanon, N., Crabbe, J.C., Nestler, E.J., Hen, R. Nature (1998) [Pubmed]
  11. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Saudou, F., Amara, D.A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., Buhot, M.C., Hen, R. Science (1994) [Pubmed]
  12. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Zhao, A., Urban, J.F., Morimoto, M., Elfrey, J.E., Madden, K.B., Finkelman, F.D., Shea-Donohue, T. Gastroenterology (2006) [Pubmed]
  13. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Cheetham, S.C., Heal, D.J. Br. J. Pharmacol. (1993) [Pubmed]
  14. Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes. Millan, M.J., Veiga, S., Girardon, S., Brocco, M. Psychopharmacology (Berl.) (2003) [Pubmed]
  15. Analysis of the nature of antagonism of the reserpine-induced hypothermia by imipramine. Francès, H. Naunyn Schmiedebergs Arch. Pharmacol. (1987) [Pubmed]
  16. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Maj, J., Kołodziejczyk, K., Rogóz, Z., Skuza, G. Pharmacopsychiatry (1997) [Pubmed]
  17. Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. Ase, A.R., Reader, T.A., Hen, R., Riad, M., Descarries, L. J. Neurochem. (2001) [Pubmed]
  18. Hyperphagia Alters Expression of Hypothalamic 5-HT2C and 5-HT1B Receptor Genes and Plasma Des-Acyl Ghrelin Levels in Ay Mice. Nonogaki, K., Nozue, K., Oka, Y. Endocrinology (2006) [Pubmed]
  19. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. Lucas, J.J., Yamamoto, A., Scearce-Levie, K., Saudou, F., Hen, R. J. Neurosci. (1998) [Pubmed]
  20. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Bonnin, A., Peng, W., Hewlett, W., Levitt, P. Neuroscience (2006) [Pubmed]
  21. Serotonergic modulation of retinal input to the mouse suprachiasmatic nucleus mediated by 5-HT1B and 5-HT7 receptors. Smith, B.N., Sollars, P.J., Dudek, F.E., Pickard, G.E. J. Biol. Rhythms (2001) [Pubmed]
  22. Serotonin 5-HT1D receptors. Hoyer, D., Schoeffter, P., Waeber, C., Palacios, J.M. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
  23. Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Lee, M.D., Somerville, E.M., Kennett, G.A., Dourish, C.T., Clifton, P.G. Psychopharmacology (Berl.) (2004) [Pubmed]
  24. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. Cappelli, A., Anzini, M., Vomero, S., Mennuni, L., Makovec, F., Doucet, E., Hamon, M., Bruni, G., Romeo, M.R., Menziani, M.C., De Benedetti, P.G., Langer, T. J. Med. Chem. (1998) [Pubmed]
  25. Coupling of serotonin 5-HT1B receptors to activation of mitogen-activated protein kinase (ERK-2) and p70 S6 kinase signaling systems. Pullarkat, S.R., Mysels, D.J., Tan, M., Cowen, D.S. J. Neurochem. (1998) [Pubmed]
  26. A regulatory role in mammalian salivary glands for 5-hydroxytryptamine receptors coupled to increased cyclic AMP production. Turner, J.T., Sullivan, D.M., Rovira, I., Camden, J.M. J. Dent. Res. (1996) [Pubmed]
  27. Modulation of serotonergic receptor signaling and cross-talk by prion protein. Mouillet-Richard, S., Pietri, M., Schneider, B., Vidal, C., Mutel, V., Launay, J.M., Kellermann, O. J. Biol. Chem. (2005) [Pubmed]
  28. The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. Plassat, J.L., Boschert, U., Amlaiky, N., Hen, R. EMBO J. (1992) [Pubmed]
  29. 5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel. Heine, M., Ponimaskin, E., Bickmeyer, U., Richter, D.W. Pflugers Arch. (2002) [Pubmed]
  30. An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors. Clement, Y., Kia, K.H., Daval, G., Verge, D. Brain Res. (1996) [Pubmed]
  31. 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function. Clifton, P.G., Lee, M.D., Somerville, E.M., Kennett, G.A., Dourish, C.T. Eur. J. Neurosci. (2003) [Pubmed]
  32. Serotonin receptors and animal models of aggressive behavior. Olivier, B., Mos, J., van Oorschot, R., Hen, R. Pharmacopsychiatry (1995) [Pubmed]
  33. Differential effects of novel ligands for 5-HT receptor subtypes on nonopioid defensive analgesia in male mice. Rodgers, R.J., Shepherd, J.K., Donát, P. Neuroscience and biobehavioral reviews. (1991) [Pubmed]
  34. Serotonin1B receptor stimulation enhances cocaine reinforcement. Parsons, L.H., Weiss, F., Koob, G.F. J. Neurosci. (1998) [Pubmed]
  35. Humanization of mouse 5-hydroxytryptamine1B receptor gene by homologous recombination: in vitro and in vivo characterization. Bonaventure, P., Umans, L., Bakker, M.H., Cras, P., Langlois, X., Luyten, W.H., Megens, A.A., Serneels, L., Van Leuven, F., Leysen, J.E. Mol. Pharmacol. (1999) [Pubmed]
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