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Gene Review

ldb-1  -  Protein LDB-1

Caenorhabditis elegans

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High impact information on ldb-1

  • The ldb-1 orthologue of Caenorhabditis briggsae has the same structure as that of C. elegans and is highly conserved throughout the open reading frame, while conservation to fly and vertebrate proteins is restricted to specific domains: the dimerization domain, the nuclear localization sequence, and the LIM interaction domain [1].
  • RNA inactivation studies suggest that C. elegans ldb-1 is not required for the differentiation of neurons that express the respective LIM-HD genes or for LIM-HD gene autoregulation [1].
  • C. elegans ldb-1 is expressed in neurogenic tissues in embryos, in all neurons in larval and adult stages, and in vulval cells, gonadal sheath cells, and some body muscle cells [1].


  1. The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function. Cassata, G., Röhrig, S., Kuhn, F., Hauri, H.P., Baumeister, R., Bürglin, T.R. Dev. Biol. (2000) [Pubmed]
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