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Gene Review

Ldb2  -  LIM domain binding 2

Mus musculus

Synonyms: AI035351, AW146358, CLIM-1, CLIM-1a, CLIM-1b, ...
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High impact information on Ldb2

  • By contrast, CLP-36 mRNA is expressed in several nonmuscle tissues, and here we demonstrate high expression of CLP-36 in epithelial cells by in situ hybridization analysis [1].
  • Our subcellular localization studies indicate that in nonmuscle cells, CLP-36 protein localizes to actin stress fibers [1].
  • Transcription factor activity of the LIM-HD proteins requires the formation of a tetrameric complex consisting of two LIM-HD molecules linked by a dimer of cofactor (Clim) molecules [2].
  • Significantly, in some cases, Lmo or Clim gene expression is robust where no LIM-HD gene expression is detectable [2].
  • Ldb2 is ubiquitous at gastrulation, and later is found in many but not all tissues, especially the anterior central nervous system (CNS) and vasculature [3].

Biological context of Ldb2

  • However, little is known about the nature of CLIM1b or the evolutionary conservation of this type of alternative splicing in amphibians and teleost fish [4].
  • Human CLIM1 and CLIM2 genes were mapped to the chromosome on 4p15.3 and 10q24-q25 regions, respectively [5].

Anatomical context of Ldb2


Analytical, diagnostic and therapeutic context of Ldb2


  1. CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. Vallenius, T., Luukko, K., Mäkelä, T.P. J. Biol. Chem. (2000) [Pubmed]
  2. Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Bulchand, S., Subramanian, L., Tole, S. Dev. Dyn. (2003) [Pubmed]
  3. Expression of LIM-domain binding protein (ldb) genes during zebrafish embryogenesis. Toyama, R., Kobayashi, M., Tomita, T., Dawid, I.B. Mech. Dev. (1998) [Pubmed]
  4. Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain. Tran, Y.H., Xu, Z., Kato, A., Mistry, A.C., Goya, Y., Taira, M., Brandt, S.J., Hirose, S. J. Biochem. (2006) [Pubmed]
  5. Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2. Ueki, N., Seki, N., Yano, K., Ohira, M., Saito, T., Masuho, Y., Muramatsu, M. J. Hum. Genet. (1999) [Pubmed]
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