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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LDB2  -  LIM domain binding 2

Homo sapiens

Synonyms: CLIM-1, CLIM1, Carboxyl-terminal LIM domain-binding protein 1, LDB-2, LDB1, ...
 
 
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High impact information on LDB2

  • These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology [1].
  • These data demonstrate one function for the LIM-binding protein Ldb1 and establish a function for the LIM-only protein Lmo2 as an obligatory component of an oligomeric, DNA-binding complex which may play a role in haematopoiesis [2].
  • We identified Ssdp proteins (previously described as sequence-specific, single-stranded-DNA-binding proteins) as components of Ldb1-associated nuclear complexes in HeLa cells [3].
  • The latter is a phosphoprotein and binds to LMO1 in its phosphorylated state and essentially all the LMO1 and LDB1 protein in the T cell line is part of the complex [4].
  • LMO4 mRNA was amplified in four of six carcinoma tissues and eight of 12 carcinoma cell lines, and LDB1 in three carcinoma tissues and 11 cell lines examined [5].
 

Biological context of LDB2

  • The LMO1 AND LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11) [4].
  • Through a combination of bioinformatics and analysis of gene-trapped mouse clones, Enkhmandakh et al. were able to deduce the modular function for a part of Ssdp1, a crucial component of the Ldb1 transcriptional complex, which plays a central role in mammalian head development [6].
  • The conditioned state of a precipitation membrane with its particular properties exists within a limited range of membrane potentials and requires certain minimum concentrations, Clim, of the generating ions in the adjoining solutions [7].
  • The farnesylation consensus motif CLIM is located in the PEX19 domain D3 [8].
  • Urodynamic assessment and quantification of prostatic obstruction before and after transurethral resection of the prostate: standardization with the aid of the computer program CLIM [9].
 

Analytical, diagnostic and therapeutic context of LDB2

  • These findings form strong arguments for including CLIM parameters in the preoperative assessment to perform a TURP [9].

References

  1. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. Deane, J.E., Mackay, J.P., Kwan, A.H., Sum, E.Y., Visvader, J.E., Matthews, J.M. EMBO J. (2003) [Pubmed]
  2. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. Wadman, I.A., Osada, H., Grütz, G.G., Agulnick, A.D., Westphal, H., Forster, A., Rabbitts, T.H. EMBO J. (1997) [Pubmed]
  3. Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Chen, L., Segal, D., Hukriede, N.A., Podtelejnikov, A.V., Bayarsaihan, D., Kennison, J.A., Ogryzko, V.V., Dawid, I.B., Westphal, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. The LMO1 AND LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Valge-Archer, V., Forster, A., Rabbitts, T.H. Oncogene (1998) [Pubmed]
  5. The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. Mizunuma, H., Miyazawa, J., Sanada, K., Imai, K. Br. J. Cancer (2003) [Pubmed]
  6. Proline-rich regions in transcriptional complexes: heading in many directions. Neduva, V., Russell, R.B. Sci. STKE (2007) [Pubmed]
  7. Precipitation membranes: III. Reversible changes of membrane properties induced by alterations in ionic concentrations. Hirsch-Ayalon, P. J. Membr. Biol. (1979) [Pubmed]
  8. Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Mayerhofer, P.U., Kattenfeld, T., Roscher, A.A., Muntau, A.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. Urodynamic assessment and quantification of prostatic obstruction before and after transurethral resection of the prostate: standardization with the aid of the computer program CLIM. Rollema, H.J., van Mastrigt, R., Janknegt, R.A. Urologia internationalis. (1991) [Pubmed]
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