Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

pgp-4 - Protein PGP-4

Caenorhabditis elegans

Mounsey, K.E. et al., Zubovych, I. et al.

Mounsey, Holt, McCarthy, Walton,

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Analytical, diagnostic and therapeutic context of p-glycoprotein

The molecule largely eludes P glycoprotein-mediated drug efflux, and an analog is currently being evaluated in clinical trials as cancer chemotherapy [1].
Although P-glycoprotein (ABC-B) sequences were not found in the EST dataset, a partial P-glycoprotein sequence was subsequently obtained using a degenerate PCR strategy and library screening [2].

References

A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Zubovych, I., Doundoulakis, T., Harran, P.G., Roth, M.G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Identification of ABC transporters in Sarcoptes scabiei. Mounsey, K.E., Holt, D.C., McCarthy, J., Walton, S.F. Parasitology (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ABCB1	Arabidopsis thaliana
pgp-3	Caenorhabditis elegans
Os08g0564300	Oryza sativa Japonica Group

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