The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ABCB1  -  ABC transporter B family member 1

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA P GLYCOPROTEIN1, ATP binding cassette subfamily B1, ATP-binding cassette B1, ATPGP1, P-GLYCOPROTEIN 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ATPGP1


Biological context of ATPGP1

  • On the basis of these and other supporting data, we hypothesize that the hydrolysis of extracellular ATP by phosphatases and ATPases may be necessary for the resistance conferred by P-glycoprotein [3].
  • The single gene mutation twd1-1 and double atpgp1-1/atpgp19-1 (atmdr1-1) mutants exhibit similar phenotypes including epinastic growth, reduced inflorescence size, and reduced polar auxin transport, suggesting that a functional TWD1-AtPGP1/AtPGP19 complex is required for proper plant development [4].
  • Seven of the nine introns in the atpgp1 gene match introns in the mammalian mdr genes to within a few nucleotides, and the positions of these suggest that P-glycoprotein genes evolved by duplication and subsequent fusion of an intron-containing primordial gene prior to the evolutionary separation of plants and mammals [5].
  • Here we examine the localization, activity, substrate specificity and inhibitor sensitivity of AtPGP1 [6].
  • Consistent with the proposed role of AtMDR1 in basipetal auxin transport, we found that expression of the auxin responsive DR5::GUS reporter gene in the central elongation zone is significantly reduced in the atmdr1-100 mutant roots treated with 1-NAA at the root tips, compared to similarly treated wild-type plants [7].

Anatomical context of ATPGP1

  • Unlike all other FKBPs, TWD1 is shown to be an integral membrane protein that colocalizes with its interacting partner AtPGP1 on the plasma membrane [4].
  • Protoplasts from Arabidopsis pgp1 leaf mesophyll cells exhibit reduced efflux of natural and synthetic auxins with reduced sensitivity to auxin efflux inhibitors [6].

Associations of ATPGP1 with chemical compounds


Physical interactions of ATPGP1

  • Mapping of protein interaction domains shows that AtPGP1 surprisingly binds to the N-terminus of TWD1 harboring the cis-trans peptidyl-prolyl isomerase-like domain and not to the tetratrico-peptide repeat domain, which has been shown to mediate protein-protein interaction [4].

Other interactions of ATPGP1


  1. PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots. Terasaka, K., Blakeslee, J.J., Titapiwatanakun, B., Peer, W.A., Bandyopadhyay, A., Makam, S.N., Lee, O.R., Richards, E.L., Murphy, A.S., Sato, F., Yazaki, K. Plant Cell (2005) [Pubmed]
  2. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Noh, B., Murphy, A.S., Spalding, E.P. Plant Cell (2001) [Pubmed]
  3. A role for ectophosphatase in xenobiotic resistance. Thomas, C., Rajagopal, A., Windsor, B., Dudler, R., Lloyd, A., Roux, S.J. Plant Cell (2000) [Pubmed]
  4. TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Geisler, M., Kolukisaoglu, H.U., Bouchard, R., Billion, K., Berger, J., Saal, B., Frangne, N., Koncz-Kalman, Z., Koncz, C., Dudler, R., Blakeslee, J.J., Murphy, A.S., Martinoia, E., Schulz, B. Mol. Biol. Cell (2003) [Pubmed]
  5. Structure of an mdr-like gene from Arabidopsis thaliana. Evolutionary implications. Dudler, R., Hertig, C. J. Biol. Chem. (1992) [Pubmed]
  6. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Geisler, M., Blakeslee, J.J., Bouchard, R., Lee, O.R., Vincenzetti, V., Bandyopadhyay, A., Titapiwatanakun, B., Peer, W.A., Bailly, A., Richards, E.L., Ejendal, K.F., Smith, A.P., Baroux, C., Grossniklaus, U., Müller, A., Hrycyna, C.A., Dudler, R., Murphy, A.S., Martinoia, E. Plant J. (2005) [Pubmed]
  7. Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport. Lin, R., Wang, H. Plant Physiol. (2005) [Pubmed]
  8. Immunophilin-like TWISTED DWARF1 Modulates Auxin Efflux Activities of Arabidopsis P-glycoproteins. Bouchard, R., Bailly, A., Blakeslee, J.J., Oehring, S.C., Vincenzetti, V., Lee, O.R., Paponov, I., Palme, K., Mancuso, S., Murphy, A.S., Schulz, B., Geisler, M. J. Biol. Chem. (2006) [Pubmed]
  9. The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use. Klein, M., Perfus-Barbeoch, L., Frelet, A., Gaedeke, N., Reinhardt, D., Mueller-Roeber, B., Martinoia, E., Forestier, C. Plant J. (2003) [Pubmed]
  10. Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts. Borner, G.H., Sherrier, D.J., Weimar, T., Michaelson, L.V., Hawkins, N.D., Macaskill, A., Napier, J.A., Beale, M.H., Lilley, K.S., Dupree, P. Plant Physiol. (2005) [Pubmed]
WikiGenes - Universities