Gene Review:
sma-5 - Protein SMA-5
Caenorhabditis elegans
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High impact information on sma-5
- Expression of the sma-5 gene in hypodermis is important for body size control, and it can function both organ-autonomously and non-autonomously [1].
- However, the number of intestinal cells or body wall muscle cells is not changed, indicating that the sma-5 mutant has much smaller cells [1].
- We propose that the sma-5 gene functions in a MAP kinase pathway to regulate body size mainly through control of cell growth [1].
- In relation to the smaller cell size, the amount of total protein is drastically decreased; however, the DNA content of the intestinal nuclei is unchanged in the sma-5 mutant [1].
Biological context of sma-5
- The sma-5 gene is expressed in intestine, excretory cell and hypodermis, and encodes homologs of a mammalian MAP kinase BMK1/ERK5/MAPK7, which was reported to control cell cycle and cell proliferation [1].
Anatomical context of sma-5
- The sma-5 mutant has much smaller intestine, body wall muscles and hypodermis than those of the wild type [1].
References
- Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans. Watanabe, N., Nagamatsu, Y., Gengyo-Ando, K., Mitani, S., Ohshima, Y. Development (2005) [Pubmed]
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