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Gene Review

tag-97  -  Protein TAG-97

Caenorhabditis elegans

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High impact information on Ets-domain

  • The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway [1].
  • Multiple ETS domain sequences were detected in a number of the lower metazoan species, providing evidence for the existence of an ets multigene family at the earliest stages of metazoan evolution [2].
  • In genetic screens for mutants with axon guidance defects, we identified an ETS-domain transcription factor, AST-1, specifically required for axon navigation in certain classes of interneurons [3].

Biological context of Ets-domain


Other interactions of Ets-domain

  • lin-1 encodes an ETS domain transcription factor that functions downstream of a Ras/MAP kinase pathway mediating induction of the 1 degrees cell fate during vulval development in the C. elegans hermaphrodite [5].


  1. The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Beitel, G.J., Tuck, S., Greenwald, I., Horvitz, H.R. Genes Dev. (1995) [Pubmed]
  2. The ets multigene family is conserved throughout the Metazoa. Degnan, B.M., Degnan, S.M., Naganuma, T., Morse, D.E. Nucleic Acids Res. (1993) [Pubmed]
  3. AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans. Schmid, C., Schwarz, V., Hutter, H. Dev. Biol. (2006) [Pubmed]
  4. Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates. Miley, G.R., Fantz, D., Glossip, D., Lu, X., Saito, R.M., Palmer, R.E., Inoue, T., Van Den Heuvel, S., Sternberg, P.W., Kornfeld, K. Genetics (2004) [Pubmed]
  5. lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans. Tiensuu, T., Larsen, M.K., Vernersson, E., Tuck, S. Dev. Biol. (2005) [Pubmed]
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