Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

tag-97 - Protein TAG-97

Caenorhabditis elegans

Tiensuu, T. et al., Beitel, G.J. et al., Degnan, B.M. et al., Schmid, C. et al., Miley, G.R. et al.

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High impact information on Ets-domain

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway [1].
Multiple ETS domain sequences were detected in a number of the lower metazoan species, providing evidence for the existence of an ets multigene family at the earliest stages of metazoan evolution [2].
In genetic screens for mutants with axon guidance defects, we identified an ETS-domain transcription factor, AST-1, specifically required for axon navigation in certain classes of interneurons [3].

Biological context of Ets-domain

We show that lin-1 is a negative regulator of vulval cell fates and encodes an ETS-domain putative transcription factor containing potential MAPK phosphorylation sites [1].
All of these lin-1 missense mutations affect highly conserved residues in the ETS domain [4].

Other interactions of Ets-domain

lin-1 encodes an ETS domain transcription factor that functions downstream of a Ras/MAP kinase pathway mediating induction of the 1 degrees cell fate during vulval development in the C. elegans hermaphrodite [5].

References

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway. Beitel, G.J., Tuck, S., Greenwald, I., Horvitz, H.R. Genes Dev. (1995) [Pubmed]
The ets multigene family is conserved throughout the Metazoa. Degnan, B.M., Degnan, S.M., Naganuma, T., Morse, D.E. Nucleic Acids Res. (1993) [Pubmed]
AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans. Schmid, C., Schwarz, V., Hutter, H. Dev. Biol. (2006) [Pubmed]
Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates. Miley, G.R., Fantz, D., Glossip, D., Lu, X., Saito, R.M., Palmer, R.E., Inoue, T., Van Den Heuvel, S., Sternberg, P.W., Kornfeld, K. Genetics (2004) [Pubmed]
lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans. Tiensuu, T., Larsen, M.K., Vernersson, E., Tuck, S. Dev. Biol. (2005) [Pubmed]

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