Gene Review:
kvs-1 - Protein KVS-1
Caenorhabditis elegans
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High impact information on kvs-1
- Here we report the cloning and functional characterization of a MiRP beta-subunit, MPS-1, and of a voltage-gated pore-forming potassium subunit, KVS-1, from the nematode Caenorhabditis elegans. mps-1 is expressed in chemosensory and mechanosensory neurons and co-localizes with kvs-1 in a subset of these [1].
Biological context of kvs-1
- Inactivation of either mps-1 or kvs-1 by RNA interference (RNAi) causes partially overlapping neuronal defects and results in broad-spectrum neuronal dysfunction, including defective chemotaxis, disrupted mechanotransduction, and impaired locomotion [1].
References
- A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans. Bianchi, L., Kwok, S.M., Driscoll, M., Sesti, F. J. Biol. Chem. (2003) [Pubmed]
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