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Gene Review

Pcdh8  -  protocadherin 8

Mus musculus

Synonyms: 1700080P15Rik, Arcadlin, Papc, Paraxial protocadherin, Protocadherin-8
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High impact information on Pcdh8

  • PCNS has 65% amino acid identity to Xenopus paraxial protocadherin (PAPC) and 42-49% amino acid identity to Pcdh 8 in human, mouse, and zebrafish genomes [1].
  • This subfamily can be further subdivided into two subgroups, named delta1-protocadherins (comprising protocadherin-1, -7, -9, and -11 or X/Y) and delta2-protocadherins (comprising protocadherin-8, -10, -17, -18, and -19) [2].
  • Alternative splicing of Pcdh8 RNA leads to the formation of two isoforms that differ in the length of the cytoplasmic domains [3].
  • The differential expression of two alternative cytoplasmic domain variants suggests that Pcdh8 may regulate cell adhesion in a variety of developmental processes, and that this may involve different intracellular interactions [3].
  • The Protocadherin 8 (Pcdh8) gene comprises three coding exons in both human and mouse, and the exon junctions are precisely conserved between these two species [3].

Analytical, diagnostic and therapeutic context of Pcdh8


  1. PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus. Rangarajan, J., Luo, T., Sargent, T.D. Dev. Biol. (2006) [Pubmed]
  2. delta-Protocadherins: a gene family expressed differentially in the mouse brain. Vanhalst, K., Kools, P., Staes, K., van Roy, F., Redies, C. Cell. Mol. Life Sci. (2005) [Pubmed]
  3. Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development. Makarenkova, H., Sugiura, H., Yamagata, K., Owens, G. Biochim. Biophys. Acta (2005) [Pubmed]
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