High impact information on ces-1

• The ces-1 and ces-2 genes of C. elegans control the programmed deaths of specific neurons [1].
• SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein [2].
• The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein [1].
• The genes ces-1 and ces-2 control the decisions of two cells in the nematode Caenorhabditis elegans to undergo programmed cell death [3].

Biological context of ces-1

• Genetic studies indicate that ces-1 and ces-2 affect the fates of the NSM sisters by regulating the genes required for all programmed cell deaths to occur [3].

Associations of ces-1 with chemical compounds

• The programmed death of the NSM sister cells is dependent on the cell-death activator EGL-1, a BH3-only protein required for programmed cell death in C. elegans, and can be prevented by a gain-of-function (gf) mutation in the cell-death specification gene ces-1, which encodes a Snail-like DNA-binding protein [4].

Other interactions of ces-1

• Mutations that cause a gain of ces-1 function or a reduction of ces-2 function prevent these cells, the sisters of the two pharyngeal NSM neurons, from dying [3].

References