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Gene Review:

Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6...

Mus musculus

Synonyms: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme, PFK-2/FBPase-2 gene A, PFK/FBPase 1

Parker, G.E. et al.

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High impact information on Pfkfb1

In liver, the upregulation of Pfkfb1 and Pfkfb3 expression is consistent with increased glycolysis, perhaps as an adaptation to altered muscle metabolism [1].

Biological context of Pfkfb1

In muscle, the downregulation of Pfkfb1 and Pfkfb3, encoding isoforms of 6-phosphofructo-2-kinase/fructose-2,6-bisphospha-tase, is consistent with decreased glycolysis [1].

References

Gene expression profiling of mice with genetically modified muscle glycogen content. Parker, G.E., Pederson, B.A., Obayashi, M., Schroeder, J.M., Harris, R.A., Roach, P.J. Biochem. J. (2006) [Pubmed]

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