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Gene Review

H20J04.4  -  Protein H20J04.4

Caenorhabditis elegans

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Disease relevance of helicase

  • Blm-deficient mice, like Bloom syndrome patients, have increased frequencies of mitotic recombination owing to a mutation in the RecQ protein-like-3 helicase gene [1].


  1. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. Suzuki, T., Minehata, K., Akagi, K., Jenkins, N.A., Copeland, N.G. EMBO J. (2006) [Pubmed]
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