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Gene Review

Recql  -  RecQ protein-like

Mus musculus

Synonyms: AI957250, ATP-dependent DNA helicase Q1, DNA-dependent ATPase Q1, RecQ protein-like 1, RecQ1, ...
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Disease relevance of Recql


High impact information on Recql

  • I also describe a hypothesis of "tissue-specific genomic instability" that accounts for the pathology behind multisymptomatic RecQ helicase syndromes [3].
  • The RecQ helicase family includes helicases that have extensive amino acid sequence homologies to the E. coli DNA helicase RecQ, which has been implicated in double-strand break repair and suppression of illegitimate recombination [3].

Biological context of Recql


  1. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. Suzuki, T., Minehata, K., Akagi, K., Jenkins, N.A., Copeland, N.G. EMBO J. (2006) [Pubmed]
  2. Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1. Kawabe, Y., Seki, M., Seki, T., Wang, W.S., Imamura, O., Furuichi, Y., Saitoh, H., Enomoto, T. J. Biol. Chem. (2000) [Pubmed]
  3. Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. Furuichi, Y. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  4. Analysis of the role of RecQ helicases in RNAi in mammals. Stein, P., Svoboda, P., Stumpo, D.J., Blackshear, P.J., Lombard, D.B., Johnson, B., Schultz, R.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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