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Gene Review:

Dbp45A - DEAD box protein 45A

Drosophila melanogaster

Synonyms: CG12759, DBP45A, Dbp45, DmRH18, Dmel\CG12759, ...

Schmucker, D. et al., Lavoie, C.A. et al., Brander, K.A. et al.

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High impact information on Dbp45A

It encodes a putative ATP-dependent RNA helicase of the DEAD box protein family, with two rare substitutions in the PTRELA and the RG-D motifs, thought to be involved in oligonucleotide binding: serine for threonine, and lysine for arginine, respectively [1].
Eukaryotic translation initiation factor eIF-4A is an ATP-dependent RNA helicase that is required for the binding of mRNA to ribosomes [2].
The predicted amino acid sequence of the Dbp45A product contains all eight highly conserved DEAD family motifs, and most closely resembles the Saccharomyces cerevisiae DRS1p among known DEAD box proteins [3].

References

The Drosophila gene abstrakt, required for visual system development, encodes a putative RNA helicase of the DEAD box protein family. Schmucker, D., Vorbrüggen, G., Yeghiayan, P., Fan, H.Q., Jäckle, H., Gaul, U. Mech. Dev. (2000) [Pubmed]
Highly conserved genes coding for eukaryotic translation initiation factor eIF-4A of tobacco have specific alterations in functional motifs. Brander, K.A., Mandel, T., Owttrim, G.W., Kuhlemeier, C. Biochim. Biophys. Acta (1995) [Pubmed]
Dbp45A encodes a Drosophila DEAD box protein with similarity to a putative yeast helicase involved in ribosome assembly. Lavoie, C.A., Harvey, M., Lasko, P.F. Biochim. Biophys. Acta (1993) [Pubmed]

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