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Gene Review:

DBP8 - ATP-dependent RNA helicase DBP8

Saccharomyces cerevisiae S288c

Synonyms: DEAD box protein 8, YHR169W

Daugeron, M.C. et al., Granneman, S. et al.

Daugeron, Linder,

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High impact information on DBP8

The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis [1].
Our results show that Dbp8p is an essential nucleolar protein required for biogenesis of the small ribosomal subunit [2].
Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis [2].

Analytical, diagnostic and therapeutic context of DBP8

The involvement of Dbp8p as a bona fide RNA helicase in ribosome biogenesis is strongly supported by the loss of Dbp8p in vivo function obtained by site-directed mutagenesis of some conserved motifs carrying the enzymatic properties of the protein family [2].

References

The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Granneman, S., Lin, C., Champion, E.A., Nandineni, M.R., Zorca, C., Baserga, S.J. Nucleic Acids Res. (2006) [Pubmed]
Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis. Daugeron, M.C., Linder, P. Nucleic Acids Res. (2001) [Pubmed]

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AgaP_AGAP005130	Anopheles gambiae str. PEST
RH36	Arabidopsis thaliana
AGOS_AER301C	Ashbya gossypii ATCC 10895
DDX49	Bos taurus
H20J04.4	Caenorhabditis elegans
DDX49	Canis lupus familiaris
ddx49	Danio rerio
Dbp45A	Drosophila melanogaster
DDX49	Gallus gallus
DDX49	Homo sapiens
KLLA0A05203g	Kluyveromyces lactis NRRL Y-1140
DDX49	Macaca mulatta
MGG_06483	Magnaporthe oryzae 70-15
Ddx49	Mus musculus
NCU06418	Neurospora crassa OR74A
Os07g0633500	Oryza sativa Japonica Group
DDX49	Pan troglodytes
Ddx49	Rattus norvegicus
dbp8	Schizosaccharomyces pombe 972h-
ddx49	Xenopus (Silurana) tropicalis

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