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Gene Review

him-6  -  Protein HIM-6

Caenorhabditis elegans

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Disease relevance of helicase


High impact information on helicase


Biological context of helicase


Other interactions of helicase

  • (v) Three meiotic mutants, him-3, him-6, and him-8, had no effect on somatic loss of the duplications but did reduce the frequency of breakage events [9].


  1. Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Kusano, K., Berres, M.E., Engels, W.R. Genetics (1999) [Pubmed]
  2. Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans. Grabowski, M.M., Svrzikapa, N., Tissenbaum, H.A. Mech. Ageing Dev. (2005) [Pubmed]
  3. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. Suzuki, T., Minehata, K., Akagi, K., Jenkins, N.A., Copeland, N.G. EMBO J. (2006) [Pubmed]
  4. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Wicky, C., Alpi, A., Passannante, M., Rose, A., Gartner, A., Müller, F. Mol. Cell. Biol. (2004) [Pubmed]
  5. Mutant rec-1 eliminates the meiotic pattern of crossing over in Caenorhabditis elegans. Zetka, M.C., Rose, A.M. Genetics (1995) [Pubmed]
  6. Coaction of DNA topoisomerase IIIalpha and a RecQ homologue during the germ-line mitosis in Caenorhabditis elegans. Kim, Y.C., Lee, M.H., Ryu, S.S., Kim, J.H., Koo, H.S. Genes Cells (2002) [Pubmed]
  7. Tests for parental imprinting in the nematode Caenorhabditis elegans. Haack, H., Hodgkin, J. Mol. Gen. Genet. (1991) [Pubmed]
  8. Deficiency of Bloom's syndrome protein causes hypersensitivity of C. elegans to ionizing radiation but not to UV radiation, and induces p53-dependent physiological apoptosis. Kim, Y.M., Yang, I., Lee, J., Koo, H.S. Mol. Cells (2005) [Pubmed]
  9. Spontaneous duplication loss and breakage in Caenorhabditis elegans. McKim, K.S., Rose, A.M. Genome (1994) [Pubmed]
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