Gene Review:
Pira6 - paired-Ig-like receptor A6
Mus musculus
Synonyms:
12M1, Pira10, p91B
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High impact information on Pira6
- One region contains a single Pir gene which is almost identical to Pira6, and the other two contain multiple Pir genes in opposite transcriptional orientations [1].
- Extensive sequence homology was found between Pira6 and Pirb from approximately 2 kb upstream of the ATG initiation site to the beginning of intron 8 [1].
- The gene for one of the activating members of the paired Ig-like receptor family, Pira6, was isolated from a genomic library and sequenced [1].
- The first of 9 exons in the approximately 8.2 kb Pira6 gene encodes the 5' untranslated region, the translation initiation site, and approximately half of the signal sequence [1].
- Potential binding sites for hemopoiesis-specific and ubiquitous transcription factors were identified upstream of the Pira6 transcription start sites that reside within the initiator consensus sequence motif [1].
References
- Genomic structure of mouse PIR-A6, an activating member of the paired immunoglobulin-like receptor gene family. Tun, T., Kubagawa, Y., Dennis, G., Burrows, P.D., Cooper, M.D., Kubagawa, H. Tissue Antigens (2003) [Pubmed]
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