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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pirb  -  paired Ig-like receptor B

Mus musculus

Synonyms: Cell-surface glycoprotein p91, Gp91, LIR-3, Leukocyte immunoglobulin-like receptor 3, Leukocyte immunoglobulin-like receptor subfamily B member 3, ...
 
 
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Disease relevance of Lilrb3

  • Further analysis revealed the presence of rearranged forms of the provirus in Gp91-expressing cells, and the production of truncated, unpackaged viral RNA [1].
 

High impact information on Lilrb3

  • Exacerbated graft-versus-host disease in Pirb-/- mice [2].
  • PIR-A and PIR-B, paired immunoglobulin-like receptors encoded, respectively, by multiple Pira genes and a single Pirb gene in mice, are relatives of the human natural killer (NK) and Fc receptors [3].
  • DESIGN AND METHODS: To investigate the effect of Gp91 cDNA on the efficiency of retroviral production from the packaging cell line, GP+envAm12, we constructed vectors containing either the native cDNA, truncated versions of the cDNA or a mutated form (LATG) in which the natural translational start codon was changed to a stop codon [1].
  • Extensive sequence homology was found between Pira6 and Pirb from approximately 2 kb upstream of the ATG initiation site to the beginning of intron 8 [4].
 

Biological context of Lilrb3

References

  1. The expression of full length Gp91-phox protein is associated with reduced amphotropic retroviral production. Bellantuono, I., Lashford, L.S., Rafferty, J.A., Fairbairn, L.J. Haematologica (2000) [Pubmed]
  2. Exacerbated graft-versus-host disease in Pirb-/- mice. Nakamura, A., Kobayashi, E., Takai, T. Nat. Immunol. (2004) [Pubmed]
  3. Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. Kubagawa, H., Chen, C.C., Ho, L.H., Shimada, T.S., Gartland, L., Mashburn, C., Uehara, T., Ravetch, J.V., Cooper, M.D. J. Exp. Med. (1999) [Pubmed]
  4. Genomic structure of mouse PIR-A6, an activating member of the paired immunoglobulin-like receptor gene family. Tun, T., Kubagawa, Y., Dennis, G., Burrows, P.D., Cooper, M.D., Kubagawa, H. Tissue Antigens (2003) [Pubmed]
  5. Characterization of paired Ig-like receptors in rats. Dennis, G., Stephan, R.P., Kubagawa, H., Cooper, M.D. J. Immunol. (1999) [Pubmed]
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