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Gene Review

mbr-1  -  Protein MBR-1

Caenorhabditis elegans

 
 
 
 
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High impact information on mbr-1

  • In addition, mbr-1 expression is regulated by UNC-86, a POU domain transcription factor, and the pruning of the excessive AIM connection is impaired in the unc-86 mutant [1].
  • A comparison of the morphology of mbr-1-expressing neurons revealed that excessive neurites connecting the left and right AIM interneurons are eliminated during larval stages in wild-type but are sustained through the adult stage in the mbr-1 mutant [1].
  • We used C. elegans as an ideal model animal for analysis of neuronal development. mbr-1 is expressed in various neurons in the head and tail ganglia [1].

References

  1. MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans. Kage, E., Hayashi, Y., Takeuchi, H., Hirotsu, T., Kunitomo, H., Inoue, T., Arai, H., Iino, Y., Kubo, T. Curr. Biol. (2005) [Pubmed]
 
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