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Prim1  -  DNA primase, p49 subunit

Mus musculus

Synonyms: AI324982, DNA primase 49 kDa subunit, DNA primase small subunit, p49
 
 
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High impact information on Prim1

  • Fourteen invariant charged residues in the smaller catalytic mouse primase subunit, p49, were changed to alanine [1].
  • The eukaryotic primase is composed of two subunits, p49 and p58, where the p49 subunit contains the catalytic active site [1].
  • Current knowledge of mouse and human conserved chromosomal regions along with the findings presented here lead to predictions of where the genes for the DNA primase subunits may be found in the human genome: the p58 subunit gene may be on human chromosome 2 and the p49 subunit gene on human chromosome 12 [2].
  • We found a 49-kDa protein (p49/STRAP) that specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4 [3].
 

Analytical, diagnostic and therapeutic context of Prim1

References

  1. Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis. Copeland, W.C., Tan, X. J. Biol. Chem. (1995) [Pubmed]
  2. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Adler, D.A., Tseng, B.Y., Wang, T.S., Disteche, C.M. Genomics (1991) [Pubmed]
  3. Identification and characterization of p49/STRAP as a novel GLUT4-binding protein. Lisinski, I., Matsumoto, H., Yver, D.R., Schürmann, A., Cushman, S.W., Al-Hasani, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions. Prussak, C.E., Almazan, M.T., Tseng, B.Y. J. Biol. Chem. (1989) [Pubmed]
 
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