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MeSH Review

Sperm-Ovum Interactions

 
 
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Disease relevance of Sperm-Ovum Interactions

 

High impact information on Sperm-Ovum Interactions

 

Biological context of Sperm-Ovum Interactions

 

Anatomical context of Sperm-Ovum Interactions

 

Associations of Sperm-Ovum Interactions with chemical compounds

  • This field will be discussed with respect to what is known about specific ADAMs and the integrins with which they interact, and what the implications are for sperm-egg interactions and for integrin function [18].
  • A specific competitive inhibitor of beta-N-acetylglucosaminidase activity, PUGNAC, inhibited sperm penetration of the zona in a dose-dependent manner, whereas a closely related beta-glucosidase inhibitor, PUGLU, had no effect on zona penetration or on beta-N-acetylglucosaminidase activity [19].
  • Sperm penetration was inhibited by cytochalasin D, which disrupts F-actin function, whereas sperm pronuclear migration was sensitive to the microtubule-depolymerizing drug, nocodazole [20].
  • Of the sugars tested, L-fucose, galactose, and N-acetylglucosamine caused the greatest inhibition of sperm penetration levels relative to controls [21].
  • With this information concerning in vivo concentrations of progesterone during capacitation and fertilization, the physiological role of progesterone in sperm-egg interactions can be addressed [22].
 

Gene context of Sperm-Ovum Interactions

  • Surprisingly, these TSGA2 isoforms appear to localize in the vicinity of the anterior acrosome, as well, suggesting that Tsga2 may also play a role in sperm-egg interaction [9].
  • The essential role of the Spam1 sperm antigen in mouse sperm-egg interactions and its gene location provide strong support for its candidacy as the gene involved in the dysfunction of mouse sperm bearing the Rb(6.16)24Lub or Rb(6.15)1Ald translocation [23].
  • The objective was to identify an association between HLA-DQA1, -DRB1 or -DPB1 genes and sperm kinematic parameters and sperm penetration of oocytes [24].
  • These observations indicate that the Gal alpha 1-->3Gal moiety is not essential to sperm-oocyte interactions leading to fertilization or to essentially normal development [25].
  • We report that 27% of fertile men are deficient for the CYRN1 gene but that all have a CYRN2 gene, suggesting that the CYRN2 gene is the orthologous mouse cyritestin gene in humans and might be involved in sperm-egg interactions [26].
 

Analytical, diagnostic and therapeutic context of Sperm-Ovum Interactions

References

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  6. Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions. Youakim, A., Hathaway, H.J., Miller, D.J., Gong, X., Shur, B.D. J. Cell Biol. (1994) [Pubmed]
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  19. Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida. Miller, D.J., Gong, X., Shur, B.D. Development (1993) [Pubmed]
  20. Pronuclear positioning and migration during fertilization in Pelvetia. Swope, R.E., Kropf, D.L. Dev. Biol. (1993) [Pubmed]
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  24. The relationship between human sperm fertilizing capacity and histocompatibility linked antigen (HLA) alleles gene sequences. Chan, P.J., Su, B.C., Kalugdan, T.H., Tredway, D.R. Hum. Reprod. (1994) [Pubmed]
  25. Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. Thall, A.D., Malý, P., Lowe, J.B. J. Biol. Chem. (1995) [Pubmed]
  26. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. Grzmil, P., Kim, Y., Shamsadin, R., Neesen, J., Adham, I.M., Heinlein, U.A., Schwarzer, U.J., Engel, W. Biochem. J. (2001) [Pubmed]
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  31. Possible relationship between in utero diethylstilbestrol exposure and male fertility. Stenchever, M.A., Williamson, R.A., Leonard, J., Karp, L.E., Ley, B., Shy, K., Smith, D. Am. J. Obstet. Gynecol. (1981) [Pubmed]
 
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