The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sperm-Ovum Interactions

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sperm-Ovum Interactions


High impact information on Sperm-Ovum Interactions


Biological context of Sperm-Ovum Interactions


Anatomical context of Sperm-Ovum Interactions


Associations of Sperm-Ovum Interactions with chemical compounds

  • This field will be discussed with respect to what is known about specific ADAMs and the integrins with which they interact, and what the implications are for sperm-egg interactions and for integrin function [18].
  • A specific competitive inhibitor of beta-N-acetylglucosaminidase activity, PUGNAC, inhibited sperm penetration of the zona in a dose-dependent manner, whereas a closely related beta-glucosidase inhibitor, PUGLU, had no effect on zona penetration or on beta-N-acetylglucosaminidase activity [19].
  • Sperm penetration was inhibited by cytochalasin D, which disrupts F-actin function, whereas sperm pronuclear migration was sensitive to the microtubule-depolymerizing drug, nocodazole [20].
  • Of the sugars tested, L-fucose, galactose, and N-acetylglucosamine caused the greatest inhibition of sperm penetration levels relative to controls [21].
  • With this information concerning in vivo concentrations of progesterone during capacitation and fertilization, the physiological role of progesterone in sperm-egg interactions can be addressed [22].

Gene context of Sperm-Ovum Interactions

  • Surprisingly, these TSGA2 isoforms appear to localize in the vicinity of the anterior acrosome, as well, suggesting that Tsga2 may also play a role in sperm-egg interaction [9].
  • The essential role of the Spam1 sperm antigen in mouse sperm-egg interactions and its gene location provide strong support for its candidacy as the gene involved in the dysfunction of mouse sperm bearing the Rb(6.16)24Lub or Rb(6.15)1Ald translocation [23].
  • The objective was to identify an association between HLA-DQA1, -DRB1 or -DPB1 genes and sperm kinematic parameters and sperm penetration of oocytes [24].
  • These observations indicate that the Gal alpha 1-->3Gal moiety is not essential to sperm-oocyte interactions leading to fertilization or to essentially normal development [25].
  • We report that 27% of fertile men are deficient for the CYRN1 gene but that all have a CYRN2 gene, suggesting that the CYRN2 gene is the orthologous mouse cyritestin gene in humans and might be involved in sperm-egg interactions [26].

Analytical, diagnostic and therapeutic context of Sperm-Ovum Interactions


  1. Relationship between human in-vitro fertilization and intracytoplasmic sperm injection and the zona-free hamster egg penetration test. Shibahara, H., Mitsuo, M., Inoue, M., Hasegawa, A., Shigeta, M., Koyama, K. Hum. Reprod. (1998) [Pubmed]
  2. Fertilization of zona-drilled mouse oocytes treated with a monoclonal antibody to the zona glycoprotein, ZP3. Conover, J.C., Gwatkin, R.B. J. Exp. Zool. (1988) [Pubmed]
  3. Mammalian sperm-egg interaction: identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm. Bleil, J.D., Wassarman, P.M. Cell (1980) [Pubmed]
  4. Involvement of fertilization antigen (FA-1) in involuntary immunoinfertility in humans. Naz, R.K. J. Clin. Invest. (1987) [Pubmed]
  5. Expression of a P-selectin ligand in zona pellucida of porcine oocytes and P-selectin on acrosomal membrane of porcine sperm cells. Potential implications for their involvement in sperm-egg interactions. Geng, J.G., Raub, T.J., Baker, C.A., Sawada, G.A., Ma, L., Elhammer, A.P. J. Cell Biol. (1997) [Pubmed]
  6. Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions. Youakim, A., Hathaway, H.J., Miller, D.J., Gong, X., Shur, B.D. J. Cell Biol. (1994) [Pubmed]
  7. Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. Kim, E., Baba, D., Kimura, M., Yamashita, M., Kashiwabara, S., Baba, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. cDNA cloning and functional analysis of ascidian sperm proacrosin. Kodama, E., Baba, T., Yokosawa, H., Sawada, H. J. Biol. Chem. (2001) [Pubmed]
  9. The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities. Hui, L., Lu, J., Han, Y., Pilder, S.H. Biol. Reprod. (2006) [Pubmed]
  10. Synchronous sperm penetration of zona-free mouse eggs in vitro. Takahashi, Y., Meno, C., Sato, E., Toyoda, Y. Biol. Reprod. (1995) [Pubmed]
  11. Potential role of alphav and beta1 integrins as oocyte adhesion molecules during fertilization in pigs. Linfor, J., Berger, T. J. Reprod. Fertil. (2000) [Pubmed]
  12. The distribution and requirements of microtubules and microfilaments during fertilization and parthenogenesis in pig oocytes. Kim, N.H., Chung, K.S., Day, B.N. J. Reprod. Fertil. (1997) [Pubmed]
  13. Mouse sperm antigens that participate in fertilization. IV. A monoclonal antibody prevents zona penetration by inhibition of the acrosome reaction. Saling, P.M. Dev. Biol. (1986) [Pubmed]
  14. Enzymatic dissection of the functions of the mouse egg's receptor for sperm. Florman, H.M., Bechtol, K.B., Wassarman, P.M. Dev. Biol. (1984) [Pubmed]
  15. Sperm-surface chymotrypsin-like protease activity required for fertilization in ascidians. Koch, R.A., Norton, M.L., Vázquez, H., Lambert, C.C. Dev. Biol. (1994) [Pubmed]
  16. Modulation of the function of boar spermatozoa via adenosine and fertilization promoting peptide receptors reduce the incidence of polyspermic penetration into porcine oocytes. Funahashi, H., Fujiwara, T., Nagai, T. Biol. Reprod. (2000) [Pubmed]
  17. Human cleavage signal-1 protein; cDNA cloning, transcription and immunological analysis. Javed, A.A., Naz, R.K. Gene (1992) [Pubmed]
  18. Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. Evans, J.P. Bioessays (2001) [Pubmed]
  19. Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida. Miller, D.J., Gong, X., Shur, B.D. Development (1993) [Pubmed]
  20. Pronuclear positioning and migration during fertilization in Pelvetia. Swope, R.E., Kropf, D.L. Dev. Biol. (1993) [Pubmed]
  21. Carbohydrate involvement in sperm-egg fusion in mice. Boldt, J., Howe, A.M., Parkerson, J.B., Gunter, L.E., Kuehn, E. Biol. Reprod. (1989) [Pubmed]
  22. Progesterone concentrations in serum, follicular fluid, and oviductal fluid of the golden hamster during the periovulatory period. Libersky, E.A., Boatman, D.E. Biol. Reprod. (1995) [Pubmed]
  23. The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes. Deng, X., Moran, J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Primakoff, P., Martin-DeLeon, P.A. Mamm. Genome (1997) [Pubmed]
  24. The relationship between human sperm fertilizing capacity and histocompatibility linked antigen (HLA) alleles gene sequences. Chan, P.J., Su, B.C., Kalugdan, T.H., Tredway, D.R. Hum. Reprod. (1994) [Pubmed]
  25. Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. Thall, A.D., Malý, P., Lowe, J.B. J. Biol. Chem. (1995) [Pubmed]
  26. Human cyritestin genes (CYRN1 and CYRN2) are non-functional. Grzmil, P., Kim, Y., Shamsadin, R., Neesen, J., Adham, I.M., Heinlein, U.A., Schwarzer, U.J., Engel, W. Biochem. J. (2001) [Pubmed]
  27. Prostate development and carcinogenesis in prolactin receptor knockout mice. Robertson, F.G., Harris, J., Naylor, M.J., Oakes, S.R., Kindblom, J., Dillner, K., Wennbo, H., Törnell, J., Kelly, P.A., Green, J., Ormandy, C.J. Endocrinology (2003) [Pubmed]
  28. Thymosin alpha-1 enhances the fertilizing capacity of human sperm cell: implication in diagnosis and treatment of male infertility. Naz, R.K., Kaplan, P., Goldstein, A.L. Biol. Reprod. (1992) [Pubmed]
  29. Enhanced penetration of zona-free hamster ova by sperm prepared by Nycodenz and Percoll gradient centrifugation. Serafini, P., Blank, W., Tran, C., Mansourian, M., Tan, T., Batzofin, J. Fertil. Steril. (1990) [Pubmed]
  30. Sperm membrane incorporation into oolemma contributes to the oolemma block to sperm penetration: evidence based on intracytoplasmic sperm injection experiments in the mouse. Maleszewski, M., Kimura, Y., Yanagimachi, R. Mol. Reprod. Dev. (1996) [Pubmed]
  31. Possible relationship between in utero diethylstilbestrol exposure and male fertility. Stenchever, M.A., Williamson, R.A., Leonard, J., Karp, L.E., Ley, B., Shy, K., Smith, D. Am. J. Obstet. Gynecol. (1981) [Pubmed]
WikiGenes - Universities