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Gene Review:

SLC10A4 - solute carrier family 10, member 4

Homo sapiens

Synonyms: MGC29802, Na(+)/bile acid cotransporter 4, Sodium/bile acid cotransporter 4, Solute carrier family 10 member 4

Splinter, P.L. et al., Jørgensen, J.R. et al.

Jørgensen, Juliusson, Henriksen, Hansen, Knudsen, Petersen, Blom, Seiger, Wahlberg,

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High impact information on SLC10A4

This revealed a distinct DA-associated profile for in particular a putative transcription factor (FLJ45455) and the uncharacterized transmembrane proteins KIAA1145 and SLC10A4 [1].
SLC10A4 was cloned in frame with an epitope tag and overexpressed in CHO cells to determine cellular localization and functional analysis of bile acid uptake [2].
We performed Northern blot analysis and RT-PCR to determine the tissue distribution of SLC10A4 [2].
Functional analysis of SLC10A4 showed no significant taurocholate uptake in the presence of sodium when compared to untransfected CHO cells [2].

References

Identification of novel genes regulated in the developing human ventral mesencephalon. Jørgensen, J.R., Juliusson, B., Henriksen, K.F., Hansen, C., Knudsen, S., Petersen, T.N., Blom, N., Seiger, A., Wahlberg, L.U. Exp. Neurol. (2006) [Pubmed]
Cloning and expression of SLC10A4, a putative organic anion transport protein. Splinter, P.L., Lazaridis, K.N., Dawson, P.A., Larusso, N.F. World J. Gastroenterol. (2006) [Pubmed]

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