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Gene Review

Satb1  -  special AT-rich sequence binding protein 1

Mus musculus

Synonyms: 2610306G12Rik, AW413156, DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1
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High impact information on Satb1

  • By contrast, in Satb1-null thymocytes, this site is marked by methylation at H3 Lys9 [1].
  • A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1 [2].
  • In support of this model, the transcriptional suppressor special AT-rich sequence-binding protein 1, a preferred caspase-6 substrate, was cleaved upon B cell stimulation [3].
  • Satb2 showed 61% amino-acid homology to Satb1 [4].
  • Consistent with previous reports in a non-superantigen in vivo anergy model, mRNA for CD18 and the transcription factor Satb1 (special AT-rich-binding protein 1) was increased in SEB-energized T cells [5].

Analytical, diagnostic and therapeutic context of Satb1


  1. Tissue-specific nuclear architecture and gene expression regulated by SATB1. Cai, S., Han, H.J., Kohwi-Shigematsu, T. Nat. Genet. (2003) [Pubmed]
  2. A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Nakagomi, K., Kohwi, Y., Dickinson, L.A., Kohwi-Shigematsu, T. Mol. Cell. Biol. (1994) [Pubmed]
  3. Caspase activity is required for stimulated B lymphocytes to enter the cell cycle. Olson, N.E., Graves, J.D., Shu, G.L., Ryan, E.J., Clark, E.A. J. Immunol. (2003) [Pubmed]
  4. Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Britanova, O., Akopov, S., Lukyanov, S., Gruss, P., Tarabykin, V. Eur. J. Neurosci. (2005) [Pubmed]
  5. Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Kurella, S., Yaciuk, J.C., Dozmorov, I., Frank, M.B., Centola, M., Farris, A.D. Genes Immun. (2005) [Pubmed]
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