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Gene Review

SATB1  -  SATB homeobox 1

Homo sapiens

Synonyms: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1
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Disease relevance of SATB1


Psychiatry related information on SATB1

  • SATB1 facilitates the nuclear localization of rp3, whereas rp3 and dynein motor activity are not essential for nuclear accumulation of SATB1 [6].

High impact information on SATB1


Biological context of SATB1


Anatomical context of SATB1


Associations of SATB1 with chemical compounds


Physical interactions of SATB1


Regulatory relationships of SATB1


Other interactions of SATB1


Analytical, diagnostic and therapeutic context of SATB1


  1. Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Liu, J., Barnett, A., Neufeld, E.J., Dudley, J.P. Mol. Cell. Biol. (1999) [Pubmed]
  2. Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. Kumar, P.P., Purbey, P.K., Ravi, D.S., Mitra, D., Galande, S. Mol. Cell. Biol. (2005) [Pubmed]
  3. SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Wen, J., Huang, S., Rogers, H., Dickinson, L.A., Kohwi-Shigematsu, T., Noguchi, C.T. Blood (2005) [Pubmed]
  4. Nuclear matrix binding regulates SATB1-mediated transcriptional repression. Seo, J., Lozano, M.M., Dudley, J.P. J. Biol. Chem. (2005) [Pubmed]
  5. The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops. de Belle, I., Cai, S., Kohwi-Shigematsu, T. J. Cell Biol. (1998) [Pubmed]
  6. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. Yeh, T.Y., Chuang, J.Z., Sung, C.H. J. Cell. Sci. (2005) [Pubmed]
  7. Transcription in the loop. G??nd??r, A., Ohlsson, R. Nat. Genet. (2006) [Pubmed]
  8. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Cai, S., Lee, C.C., Kohwi-Shigematsu, T. Nat. Genet. (2006) [Pubmed]
  9. SATB1 targets chromatin remodelling to regulate genes over long distances. Yasui, D., Miyano, M., Cai, S., Varga-Weisz, P., Kohwi-Shigematsu, T. Nature (2002) [Pubmed]
  10. Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. Kieffer, L.J., Greally, J.M., Landres, I., Nag, S., Nakajima, Y., Kohwi-Shigematsu, T., Kavathas, P.B. J. Immunol. (2002) [Pubmed]
  11. The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation. Sun, Y., Wang, T., Su, Y., Yin, Y., Xu, S., Ma, C., Han, X. Cell Biol. Int. (2006) [Pubmed]
  12. The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression. Liu, J., Bramblett, D., Zhu, Q., Lozano, M., Kobayashi, R., Ross, S.R., Dudley, J.P. Mol. Cell. Biol. (1997) [Pubmed]
  13. A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. Nakagomi, K., Kohwi, Y., Dickinson, L.A., Kohwi-Shigematsu, T. Mol. Cell. Biol. (1994) [Pubmed]
  14. The matrix attachment region-binding protein SATB1 interacts with multiple elements within the gp91phox promoter and is down-regulated during myeloid differentiation. Hawkins, S.M., Kohwi-Shigematsu, T., Skalnik, D.G. J. Biol. Chem. (2001) [Pubmed]
  15. Tal1/SCL binding to pericentromeric DNA represses transcription. Wen, J., Huang, S., Pack, S.D., Yu, X., Brandt, S.J., Noguchi, C.T. J. Biol. Chem. (2005) [Pubmed]
  16. SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Li, K., Cai, R., Dai, B.B., Zhang, X.Q., Wang, H.J., Ge, S.F., Xu, W.R., Lu, J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  17. Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation. Yamaguchi, H., Tateno, M., Yamasaki, K. J. Biol. Chem. (2006) [Pubmed]
  18. The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11. Durrin, L.K., Krontiris, T.G. Genomics (2002) [Pubmed]
  19. Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization. Xu, L., Deng, H.X., Xia, J.H., Yang, Y., Fan, C.H., Hung, W.Y., Siddque, T. Cytogenet. Cell Genet. (1997) [Pubmed]
  20. The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein. Cunningham, J.M., Purucker, M.E., Jane, S.M., Safer, B., Vanin, E.F., Ney, P.A., Lowrey, C.H., Nienhuis, A.W. Blood (1994) [Pubmed]
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